Glyan Duo Tablets 5/500 mg (Empagliflozin, Metformin Hydrochloride)

Adult dose

The recommended dosage is one tablet, twice daily. Dosage should be determined considering each patient's current treatment regimen, efficacy, and tolerability, not exceeding the maximum recommended daily amounts of 25 mg of Empagliflozin and 2000 mg of Metformin. Patients unable to achieve sufficient blood sugar control with Metformin alone or in combination therapy with other medications such as insulin should take 5 mg of Empagliflozin twice daily (a total of 10 mg daily) along with their current metformin dosage.

This medication lowers blood sugar; however, it should not be used by patients with significantly impaired kidney function, severe infections, heart problems, or liver dysfunction. During treatment, there is a risk of a rare but serious side effect called lactic acidosis, so if any unusual symptoms occur, consult a doctor immediately. Additionally, when using this medication in conjunction with insulin or other antihyperglycemic agents, the risk of hypoglycemia exists, so caution is required, and dosages of the antihyperglycemic agents may need adjustment if deemed necessary. If undergoing tests that use iodinated contrast agents, the use of this medication should be temporarily suspended before and after the procedure, and resumption should only occur after confirming normal kidney function. Women who are pregnant or breastfeeding should avoid taking this medication, and elderly patients or those with weak kidney function should undergo regular kidney function tests. This medication can increase urination, which may lead to dehydration or low blood pressure; therefore, patients who have dehydration symptoms or low blood pressure should be particularly cautious. During treatment, urinary or genital infections may occur, so any signs of infection require immediate medical attention, and vitamin B12 levels may decrease, so long-term users should have blood tests to monitor this. It is advisable to avoid alcohol consumption during treatment, and in case of acute illness or surgery while taking this medication, consult a doctor to consider temporarily halting medication use. Finally, this medication's safety and efficacy have not been established in children, so it is not recommended for patients under 18 years of age.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, lactic acidosis, ketoacidosis, angioedema, necrosis of the perineum, pyelonephritis, urinary sepsis, liver abnormalities (jaundice), acute cholecystitis, autoimmune hepatitis, hepatitis, severe skin reactions (severe rash with fever, blisters, skin peeling, pain in oral/ocular mucosa), cerebral infarction, seizures, altered consciousness, visual disturbances, paralysis, myocardial infarction, heart failure, acute kidney

Mild side effects

• Hypoglycemia
• urinary tract infection
• genital infection
• increased urination
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• constipation

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. It is important to maintain a storage temperature between 1 to 30 degrees Celsius.

Appearance

Orange-yellow oval film-coated tablet with a double convex shape

Package unit

30 tablets/box [(6 tablets/PTP x 5)]