Jadis Duo Tablets 5/500 mg (Empagliflozin, Metformin)

Adult dose

The recommended dose of this drug is 1 tablet, twice a day. For patients who do not achieve adequate blood glucose control with metformin alone or in combination with other medications such as insulin, empagliflozin 5 mg should be taken twice daily (total of 10 mg), and if tolerability is good, the dosage can be increased to 10 mg to 25 mg. Patients using a combination therapy of empagliflozin and metformin should administer their existing dosage. This drug is for use with meals.

This drug can cause severe lactic acidosis, so it should not be used in patients with poor kidney function, severe infection, or dehydration. Additionally, caution should be taken as there is a risk of hypoglycemia when taken with insulin or sulfonylureas. This drug is not administered to patients with moderate to severe kidney dysfunction or in situations where acute kidney injury is anticipated. Patients with acute heart disease, heart failure, liver dysfunction, pregnant or breastfeeding women should also avoid this drug. Regular kidney function tests should be conducted before and during use of this drug, especially in elderly patients or those with diminished kidney function. This drug can influence body fluid volume and carries a risk of dehydration or low blood pressure, so caution should be exercised in patients with dehydration symptoms or low blood pressure. During treatment, patients must be alert to symptoms of hypoglycemia resulting from excessively low blood sugar, and should be cautious about irregular meals or excessive exercise as these may increase risks. Genital and urinary infections may occur, so if related symptoms arise, consultation with a doctor should be sought immediately. Women who are pregnant or planning to become pregnant should not use this drug, and breastfeeding women are also advised to avoid it. If surgery is planned or diagnostic tests using iodinated contrast agents are to be conducted, this drug should be temporarily discontinued, and it should only be resumed after confirming that kidney function is normal. In cases of overdose, serious side effects such as lactic acidosis may occur, so immediate medical attention is required. This drug has not been established as safe and effective in children, so it should not be used in individuals under 18 years of age. Elderly patients carry a higher risk of kidney dysfunction and fluid loss, thus requiring dosage adjustments and monitoring of kidney function. Alcohol consumption may increase the risk of lactic acidosis, so it is advisable to avoid it while taking this medication. During the use of this drug, it is important to consult with a healthcare professional if abnormal symptoms occur, and to regularly check for any side effects.

Serious side effects

• Severe lactic acidosis
• lactic acidosis
• ketoacidosis
• urticaria
• angioedema
• severe rash with high fever
• blisters
• skin peeling
• oral/eye mucosal pain
• perineal necrosis

Mild side effects

• Hypoglycemia
• urinary tract infection
• genital infection
• increased urination
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• constipation

This drug should be stored in a tightly closed container to avoid exposure to air or moisture, ideally at room temperature between 1 and 30 degrees Celsius. Taking these precautions will help maintain the drug's effectiveness.

Appearance

Orange-yellow, biconvex, oval film-coated tablet

Package unit

10 tablets/box [10 tablets/PTP x 1], 30 tablets/bottle, 60 tablets/box [10 tablets/PTP x 6], 60 tablets/bottle