Empagliflozin/Metformin Film-Coated Tablets 5/1000 mg

Adult dose

The recommended dosage for this drug is one tablet, twice a day. Dosage is determined based on the patient's condition, within the maximum recommended dose of empagliflozin of 25 mg and metformin of 2000 mg. In cases where blood sugar control is difficult with metformin alone or in combination with other medications like insulin, empagliflozin 5 mg twice a day and the existing dose of metformin is recommended. If there is good tolerance and additional blood sugar control is required, dosage may be increased to empagliflozin 25 mg daily.

This medication is used to help lower blood sugar levels in diabetic patients. When taking this medication, there is a risk of rare side effects such as serious lactic acidosis, so caution is necessary. In addition, using this medication with other diabetes drugs like insulin or sulfonylureas may increase the risk of hypoglycemia, so care is needed. This medication should not be used in patients with significant renal impairment, acute renal issues, severe infections, heart failure, or type 1 diabetes. If an iodinated contrast agent for radiological examinations is planned, temporarily discontinue this medication before and after the test. Patients about to undergo surgery should also stop taking this medication 48 hours prior and resume only when their kidney function returns to normal. Patients with poor liver function, severe pulmonary diseases, or excessive alcohol consumption should avoid this medication. Pregnant or breastfeeding women should not take this medication, and those breastfeeding are advised to discontinue use. Regular monitoring of kidney function and serum creatinine levels is necessary during treatment. This medication may increase urination, and the risk of urinary tract infections or genital infections may climb, so consult a doctor immediately if symptoms of infection appear. Hypotension or dehydration due to fluid loss can occur, hence caution is needed in cases of dehydration symptoms or reduced fluid volume risk. Vitamin B12 levels may decrease, so patients taking this medication long-term should regularly check their Vitamin B12 levels. Hypoglycemia symptoms may occur, so especially when taken with other hypoglycemic agents, blood sugar changes should be carefully monitored. Alcohol can increase the risk of lactic acidosis, hence excess drinking should be avoided while on this medication. If pain, swelling, or redness occurs around the genital area during the course of treatment, inform healthcare providers immediately as there may be a serious infection like perineal necrosis. Elderly patients or those with poor kidney function may need dose adjustments and regular testing; it is safe to stay within the maximum prescribed dose. In case of an overdose, serious side effects may appear, so take the exact dose as prescribed by a physician and receive appropriate treatment at a hospital if necessary. This medication is not recommended for children and it is advisable not to use it for individuals under 18 years old.

Serious side effects

• Hives
• angioedema
• ketoacidosis
• lactic acidosis
• perineal necrosis
• urosepsis
• pyelonephritis
• acute kidney injury
• acute pyelonephritis
• renal function impairment

Mild side effects

• Hypoglycemia
• urinary tract infections
• genital infections
• increased urination
• nausea
• vomiting
• diarrhea
• abdominal pain
• loss of appetite
• constipation

This medication may be sensitive to air or moisture, so it should be stored in a sealed container. The storage temperature should be maintained at room temperature between 1 to 30 degrees Celsius. This will help retain the medication's effectiveness and safety.

Appearance

Biconvex oval film-coated tablet, yellow with a brown tint

Package unit

10 tablets/box [10 tablets/PTP x 1], 60 tablets/box [10 tablets/PTP x 6], 60 tablets/bottle