Tenegliptin Extended-Release Tablets 10/750 mg (Tenegliptin Hydrochloride Hydrate, Metformin Hydrochloride)

Adult dose

This medication is generally taken once daily with the evening meal, with gradual dosage adjustment to reduce gastrointestinal side effects associated with metformin. For the 20/1000 mg extended-release tablet, take 1 tablet once daily. For patients taking the 10/750 mg or 10/500 mg extended-release tablets, take 2 tablets simultaneously once daily. If sufficient blood sugar control cannot be achieved with metformin monotherapy, the initial dosage of this medication should provide metformin's existing dosing along with tenegliptin 20 mg once daily. For patients transitioning from combined therapy with tenegliptin and metformin to this medication, the starting dosage can be the existing dosing of tenegliptin and metformin. Blood sugar control should be closely monitored and dosage adjustments should be made appropriately when converting from short-acting to extended-release metformin. When co-administered with sulfonylureas, consideration should be given to reducing the sulfonylurea dose to minimize the risk of hypoglycemia. The maximum recommended dosage is tenegliptin 20 mg and extended-release metformin 2000 mg. The safety and efficacy of this medication have not been specifically evaluated in patients transitioned from other hypoglycemic agents. Any changes in diabetes treatment for type 2 diabetes patients should be closely monitored due to potential changes in blood sugar control. To maintain its extended-release properties, this medication should be swallowed whole and not be divided, crushed, chewed, or otherwise manipulated.

This medication is used for controlling blood sugar. However, there are several points to be cautious about when taking this medication. First, it can rarely cause a serious condition called lactic acidosis. Lactic acidosis can be dangerous due to excessive accumulation of lactic acid in the body, so if symptoms such as lethargy, abdominal pain, or difficulty breathing occur, consult a doctor immediately. Second, taking it alongside other diabetes medications or insulin can cause hypoglycemia, so it is important to monitor blood sugar levels carefully. Third, patients with impaired kidney function, severe heart disease, liver dysfunction, or those with severe infection or traumatic systemic disorders should not take this medication. Fourth, stop taking this medication at least 48 hours before undergoing tests that use iodine contrast agents, and only resume after confirming normal kidney function post-examination. Fifth, it is advisable for pregnant women or women who could become pregnant, individuals with very poor nutritional status, or patients who are in a state of starvation or weakness not to take this medication. Sixth, avoid alcohol intake while taking this medication, and especially be cautious in situations where acute alcohol intoxication is a risk. Seventh, side effects such as gastrointestinal disturbances, dizziness, joint pain, and skin rashes may occur in some patients, so report any unusual symptoms to a doctor. Finally, elderly patients or those with reduced kidney function should have regular kidney function tests and adjust their dosage as necessary. It is essential to be aware of symptoms of hypoglycemia and lactic acidosis while taking this medication, and to consult healthcare personnel immediately if symptoms arise.

Serious side effects

Hives, severe swelling (edema), difficulty breathing, chest tightness, cold sweat, pallor, and other severe allergic reaction symptoms; high fever and severe rash, blisters, detachment of skin, pain in mucous membranes of mouth/eyes, severe skin reactions; acute pancreatitis; jaundice symptoms due to liver dysfunction; sudden and very severe headache, confusion, visual disturbances, serious neurological symptoms such as seizures, and significant changes in urinary output.

Mild side effects

• Hypoglycemia
• constipation
• dizziness
• abdominal pain
• diarrhea
• indigestion
• vomiting
• itching
• rash
• headache

Store this medication in a tightly sealed container to keep air out, with a recommended storage temperature between 1 degree and 30 degrees Celsius. Proper storage maintains the medication's effectiveness and prevents deterioration.

Appearance

Yellow oval-shaped extended-release film-coated tablet

Package unit

30 tablets/bottle