Janugliptin Met Formulation 50/1000 mg

Adult dose

This medication is generally taken twice daily with food, and the dosage should be gradually increased to minimize gastrointestinal side effects caused by metformin. 1. Patients not currently treated with metformin: This drug can be taken as 50/500 mg, 1 tablet twice daily, and can be increased to 50/1000 mg as 1 tablet twice daily. 2. Patients receiving treatment with metformin:

This medication may cause severe allergic reactions, so if symptoms such as rash, difficulty breathing, or swelling of the face or neck occur, it should be immediately discontinued and medical consultation sought. During treatment, inflammation of the pancreas (pancreatitis) may arise; if symptoms like abdominal pain, vomiting, or loss of appetite occur, consult a physician immediately. Patients with severe renal impairment, heart failure, acute myocardial infarction, or other serious conditions should not use this medication, and may need to temporarily discontinue it prior to certain tests. It is safest for women who are pregnant, potentially pregnant, or breastfeeding to refrain from using this medication. This medication can induce hypoglycemia, so caution is needed if meals are skipped, there are irregular eating habits, or excessive exercise occurs. Regular kidney function and blood tests should be performed during treatment, and it is advisable to check vitamin B12 levels as well. Alcohol consumption may increase the risk of side effects from this medication, so drinking should be avoided while on this treatment. If surgery is planned, this medication should be temporarily halted 48 hours before the procedure and resumed only after kidney function has been confirmed to be normal post-surgery. Gastrointestinal disturbances such as diarrhea, nausea, vomiting, abdominal pain, headache may occur during treatment, and signs of hypoglycemia may also need attention. Rarely, severe joint pain, skin rash, or blistering skin diseases may occur; immediate consultation with a physician is necessary if symptoms are severe. This medication can have interactions with other antidiabetic drugs or specific medications; therefore, it is essential to inform healthcare providers of any other ongoing medications. Elderly patients or those with reduced kidney function should be particularly cautious during use, requiring dose adjustments and regular monitoring. In case of overdose, immediate medical attention should be sought, and some components can be removed by dialysis.

Serious side effects

Hives, severe swelling, anaphylaxis, angioedema, severe rash, exfoliative dermatitis (including Stevens-Johnson syndrome), blistering dermatitis, acute pancreatitis, acute kidney failure, difficulty breathing, acute and unstable heart failure, acute myocardial infarction, severe lactic acidosis, severe hypoglycemia, severe and persistent joint pain, severe allergic reactions, serious neurological symptoms (headache, confusion, seizures, etc.), liver abnormalities (jaundice)

Mild side effects

• Diarrhea
• upper respiratory tract infections
• headache
• nausea
• vomiting
• abdominal pain
• nasopharyngitis
• constipation
• muscle pain
• limb pain

This medication should be stored in an airtight container that allows for good air circulation, and it is recommended to be stored at room temperature between 1 to 30 degrees Celsius. This storage method will help maintain the medication's effectiveness and prevent deterioration.

Appearance

Pink oval film-coated tablets

Package unit

30 tablets/box [10 tablets/PTP x 3]