Aminet Tablet 50/850 mg

Adult dose

This drug is generally taken twice a day with food, with a gradual increase in dosage. 1. For patients not currently being treated with metformin: Take this drug 50/500 mg, 1 tablet twice daily, and increase to 50/1000 mg, 1 tablet twice daily. 2. For patients already on metformin treatment: Sitagliptin 50 mg twice daily (total 100 mg) and the existing metformin dose.

This drug is a combination medication containing sitagliptin and metformin hydrochloride. First, hypersensitivity reactions may occur while taking this drug. If symptoms such as rash, urticaria, difficulty in breathing, or swelling of the face or lips occur, stop taking the drug immediately and consult a doctor. Second, serious side effects such as acute pancreatitis, which involves inflammation of the pancreas, have been reported rarely. If symptoms such as abdominal pain, nausea, vomiting, or fever occur, inform medical personnel immediately and stop taking the medication. Third, metformin can cause a rare but serious metabolic disorder known as lactic acidosis. Patients with reduced kidney function, severe infections, dehydration, or heart failure should not take this drug, and symptoms such as fatigue, muscle pain, difficulty breathing, and abdominal pain should prompt immediate medical attention. Fourth, this drug should not be used in patients with reduced kidney function, acute diseases that may affect kidney function such as acute myocardial infarction or sepsis, unstable heart failure patients, pregnant or breastfeeding women, and children and teenagers under 18. Fifth, there is an increased risk of hypoglycemia in patients with irregular eating patterns, poor nutrition, or engaging in vigorous exercise, or when used in combination with other hypoglycemic agents, thus caution is required. Sixth, regular kidney function and blood tests should be conducted while taking this medication, and it is advisable to check vitamin B12 levels as well. Seventh, the use of this drug should be suspended for a certain period before and after surgery, and kidney function should be checked before resuming use. Eighth, excessive alcohol consumption should be avoided while taking this drug, as alcohol can increase the risk of lactic acidosis. Ninth, sitagliptin and metformin may interact with other medications, so if you are taking any other drugs, you must inform your doctor or pharmacist. Lastly, in case of an overdose of this drug, seek medical attention immediately; some components can be removed through dialysis.

Serious side effects

Urticaria, severe swelling (edema), anaphylaxis, angioedema, rash, exfoliative skin reaction, Stevens-Johnson syndrome, acute pancreatitis, acute renal failure, difficulty breathing, severe and debilitating joint pain, blistering dermatitis, liver abnormalities (increased liver enzyme levels, potential jaundice), hypoglycemia, severe hypoglycemia, acute renal failure, severe edema, unstable angina, difficulty breathing, acute pancreatitis, anaphylaxis, angioedema, urticaria

Mild side effects

• Diarrhea
• upper respiratory tract infection
• headache
• nausea
• vomiting
• abdominal pain
• constipation
• nasopharyngitis
• muscle pain
• limb pain

This drug should be stored in a tightly sealed container to prevent air ingress and ideally kept at room temperature between 1 degree and 30 degrees Celsius. This helps maintain the drug's effectiveness for a long period.

Appearance

Pink oval film-coated tablet

Package unit

30 tablets/box [(10 tablets/PTP x 3)]