Animet Tablet 50/500 mg

Adult dose

This medicine is generally taken twice daily with food, and the dosage should be gradually increased to reduce gastrointestinal side effects associated with metformin. 1. Patients not currently treated with metformin: Take this medicine 50/500 mg twice daily at a dose of one tablet per intake, and it could be increased to 50/1000 mg, also taken twice daily at one tablet per intake. 2. Patients already receiving treatment with metformin:

This medicine contains two ingredients: sitagliptin and metformin, which are antidiabetic agents. First, serious allergic reactions may occur during treatment with this medicine; therefore, discontinue use immediately and inform medical staff if symptoms such as skin rash, difficulty breathing, or swelling of the face or neck occur. Second, pancreatitis, an inflammation of the pancreas, can occur rarely; therefore, if symptoms such as abdominal pain, nausea, vomiting, or fever arise, visit a hospital immediately. Third, due to the metformin component, lactic acidosis, a rare but potentially fatal metabolic disorder, can occur; hence, inform medical personnel immediately if sudden fatigue, muscle pain, difficulty breathing, or abdominal pain occurs. Fourth, this medicine should not be used by patients with moderate to severe renal impairment, acute heart failure, severe infections, or those who are pregnant or breastfeeding. Fifth, regular monitoring of renal function and blood tests is required while using this medicine, especially in elderly patients or those with weakened renal function. Sixth, this medicine may cause hypoglycemia; caution should be taken when skipping meals or engaging in strenuous exercise, as the risk of hypoglycemia may increase when taken with other hypoglycemic agents. Seventh, alcohol consumption can increase the risk of lactic acidosis, so it is advisable to avoid drinking while taking this medication. Eighth, patients scheduled for surgery should discontinue this medicine 48 hours before surgery and may resume use after renal function is confirmed to be normal post-surgery. Ninth, if blisters or severe joint pain occur while taking this medicine, notify medical staff immediately. Finally, the safety and efficacy of this medicine in children and adolescents have not been established, so it should not be used in these populations.

Serious side effects

• Urticaria, angioedema, anaphylaxis, exfoliative skin diseases such as Stevens-Johnson syndrome → severe allergic reactions
• Acute pancreatitis (including fatal/non-fatal hemorrhagic or necrotizing pancreatitis)
• Acute renal failure (sometimes requiring dialysis)
• Difficulty breathing
• Acute and unstable heart failure
• Acute myocardial infarction
• Increased liver enzymes and liver abnormalities (jaundice symptoms not specified, but liver abnormalities included)
• Severe and disabling joint pain
• Vesiculobullous conditions

Mild side effects

• Diarrhea
• upper respiratory tract infections
• headache
• nausea
• vomiting
• abdominal pain
• nasopharyngitis
• constipation
• muscle pain
• limb pain

This medicine should be stored in an airtight, sealed container, ideally at room temperature between 1 and 30 degrees Celsius. Storing it this way will help maintain the medicine's effectiveness and prevent deterioration.

Appearance

Bright pink oval film-coated tablets

Package unit

30 tablets/box [(10 tablets/PTP x 3)]