Sinubiem Tablet 50/1000 mg (Sitagliptin, Metformin)

Adult dose

In diabetes treatment, the dosage of this medication is determined considering the patient's treatment regimen, efficacy, and tolerability, without exceeding a maximum daily dose of 100 mg of sitagliptin and 2000 mg of metformin. Generally, it is taken twice daily with food, and the dose should be gradually increased to reduce gastrointestinal side effects caused by metformin. 1. For patients not treated with metformin: The initial dosage is 50/500 mg.

This medication contains the active ingredients sitagliptin and metformin, and is used for diabetes treatment. First, this medication may cause rare but serious allergic reactions, so if symptoms such as rash, urticaria, or swelling of the face or neck appear, it is important to stop taking it immediately and consult a doctor. Second, acute pancreatitis may occur; thus, if sudden abdominal pain, vomiting, or nausea occurs, one should visit a hospital immediately. Third, lactic acidosis, a serious metabolic disorder, may occur due to the metformin component, so it is contraindicated for individuals with poor kidney function, dehydration, severe infections, or heart issues. If any symptoms are suspected, it is crucial to inform a healthcare professional immediately. Fourth, patients with moderate to severe impairment of kidney function, severe heart disease, those in acute infection states, and women who are pregnant or breastfeeding should not use this medication. Fifth, while taking this medication, regular monitoring of kidney function, blood tests, and vitamin B12 levels is necessary, especially for the elderly, as they are more prone to kidney function decline. Sixth, there is a risk of hypoglycemia, so meals should be regular, and vigorous exercise or alcohol consumption should be avoided, particularly if taken with other hypoglycemic agents where symptoms of hypoglycemia require extra caution. Seventh, before surgery or radiographic examinations involving contrast agents, this medication should be temporarily withheld and resumed only after normal kidney function is confirmed. Eighth, there are various drugs that may interact with this medication, so it is essential to inform a doctor or pharmacist of any other medications being taken, especially those affecting kidney function. Finally, the safety and efficacy of this medication have not been established in children or adolescents under 18 years of age, so its use is not recommended.

Serious side effects

• Urticaria
• angioedema
• anaphylaxis
• Stevens-Johnson syndrome
• rash
• cutaneous vasculitis
• exfoliative dermatitis
• acute pancreatitis
• acute renal failure
• respiratory distress

Mild side effects

• Diarrhea
• nausea
• vomiting
• abdominal pain
• headache
• upper respiratory infection
• nasopharyngitis
• constipation
• weakness
• thrombocytopenia

This medication should be stored in a well-closed container that allows for air circulation, at room temperature between 1°C and 30°C. This helps maintain its efficacy and prevent degradation.

Appearance

Pink oval film-coated tablet

Package unit

30 tablets/box [(10 tablets/PTP x 3)]