Sinuvim Tablets 50/850 mg (Sitagliptin, Metformin)

Adult dose

This medication is generally taken twice a day with food, with gradual dose escalation to reduce gastrointestinal side effects from metformin. 1. Patients currently not receiving metformin: Start with an initial dose of 50/500 mg twice daily, taking 1 tablet per dose, with potential escalation to 50/1000 mg. 2. Patients receiving metformin treatment: The recommended initial dose is sitagliptin.

This medication contains sitagliptin and metformin, and is used in diabetes treatment. First, during the administration of this medication, severe allergic reactions may occur, so if symptoms such as rash, hives, difficulty breathing, or swelling of the face or neck arise, you should stop taking the medication immediately and inform a healthcare professional. Furthermore, there is a risk of developing acute pancreatitis, a serious inflammation of the pancreas, so symptoms such as abdominal pain, nausea, vomiting, and fever should be closely monitored, and if suspected, consult a doctor immediately. Metformin, one of the ingredients in this medication, can rarely provoke a serious metabolic disorder called lactic acidosis, which may manifest as muscle pain, difficulty breathing, weakness, and abdominal pain. If these symptoms appear, you must stop taking the medication immediately and seek emergency treatment. Patients with severely impaired kidney function, acute cardiac failure, severe infection, or dehydration should not take this medication and should discontinue it before and after examinations using contrast media containing iodine. It is safer not to use this medication in pregnant women or women who may become pregnant, or in nursing mothers. During the course of treatment, symptoms of hypoglycemia may occur, so especially when taken with other hypoglycemic agents or insulin, blood sugar levels should be monitored frequently and attention should be paid to symptoms of hypoglycemia. Additionally, there is an increased risk of hypoglycemia during intense exercise, irregular meals, or poor nutritional status, so caution is needed. Regular monitoring of liver and kidney function during treatment is necessary to ensure there are no abnormalities, and since vitamin B12 deficiency may occur, it is advisable to periodically check vitamin levels. Alcohol consumption may increase risks when taken with this medication, so it is preferable to avoid alcohol. During states where oral ingestion is difficult due to surgery, severe infection, or significant trauma, temporarily discontinuing this medication and restarting it after recovery is necessary. Finally, joint pain, skin rash, or blistering skin diseases may develop during treatment, so if such symptoms appear, consult a physician.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, anaphylaxis, angioedema, Stevens-Johnson syndrome, severe rash with fever, blisters, skin peeling, pain in oral/ocular mucosa, shortness of breath or difficulty breathing, asthma attack, respiratory abnormalities accompanied by cough and fever, yellowing of skin or eyes (jaundice), profound systemic fatigue, sudden and severe headache, lightning headache, seizures, loss of consciousness

Mild side effects

• Diarrhea
• nausea
• vomiting
• abdominal pain
• upper respiratory infection
• nasopharyngitis
• headache
• thrombocytopenia
• muscle pain
• limb pain

Store this medication in a tightly closed container to prevent air exposure, and it is best kept at room temperature between 1 to 30 degrees Celsius. Proper storage conditions help maintain the medication's effectiveness.

Appearance

Pink oval film-coated tablet

Package unit

30 tablets/box [(10 tablets/PTP x 3)]