DS Plus Tablet 10/100 mg (Dapagliflozin Citrate, Sitagliptin Hydrochloride Hydrate)

Adult dosage

This medication can be administered to patients taking sitagliptin 100 mg and dapagliflozin 10 mg as a 1 tablet daily regardless of meals. The tablet should be swallowed whole.

This medication is a combination drug that contains sitagliptin and dapagliflozin and is used for the treatment of type 2 diabetes. First, this drug may cause serious allergic reactions in some patients, so if symptoms such as skin rash, anaphylaxis, or angioedema appear within three months of starting therapy, users should immediately discontinue use and consult a healthcare professional. Furthermore, a serious side effect called pancreatitis, which involves inflammation of the pancreas, may occur, so if symptoms such as severe abdominal pain, vomiting, or fever develop during usage, patients should seek medical attention immediately. This medication should not be used in patients with type 1 diabetes, diabetic ketoacidosis, specific genetic issues like lactose intolerance, or those undergoing dialysis. Patients with reduced kidney function, decreased fluid volume, or elderly patients should use this medication with caution, and kidney function, blood pressure, and fluid status should be thoroughly checked and monitored before and during treatment. This drug may increase the risk of genital infections and urinary tract infections; therefore, it is important to seek prompt treatment if infection symptoms appear. Due to the risk of hypoglycemia, particularly when used in combination with insulin or sulfonylureas, blood sugar levels should be frequently monitored, and medication dosages adjusted as necessary. During treatment, attention should be paid to signs of dehydration, hypotension, or symptoms of ketoacidosis (such as nausea, vomiting, abdominal pain, and difficulty breathing), and if suspected, immediate consultation with a physician is advised. It is recommended that women who are pregnant or breastfeeding refrain from using this medication; if pregnancy is confirmed, use should be discontinued immediately. Safety and efficacy in children under 18 years of age have not been established, so it is advisable not to use this medication in that population. In case of overdose, patients should promptly visit a medical institution for appropriate treatment, and side effects of this medication may include weight loss, decreased blood pressure, headache, back pain, dry mouth, constipation, and itching. Caution is needed while driving or operating machinery during treatment, especially in cases of hypoglycemia. Finally, this medication should be stored in its original container and kept safely out of reach of children.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, anaphylaxis, angioedema, Stevens-Johnson syndrome, severe hypersensitivity reactions, acute pancreatitis, fatal/non-fatal hemorrhagic or necrotizing pancreatitis, ketoacidosis, diabetic ketoacidosis, urosepsis, pyelonephritis, acute kidney injury, renal dysfunction, rash, blisters, skin peeling, mucosal pain in mouth/eyes, skin allergic reactions, difficulty breathing

Mild side effects

Vulvovaginitis, balanitis and related genital infections, urinary tract infections, fungal infections, hypoglycemia, dry mouth, constipation, back pain, polyuria, nocturia, vulvar itching, genital itching, increased hematocrit, decreased renal creatinine clearance at treatment initiation, dyslipidemia, increased serum creatinine at treatment initiation, elevated blood urea levels, weight loss, dizziness, gastrointestinal disturbances (abdominal discomfort, abdominal pain, vomiting, indigestion,

This medication may be sensitive to air or moisture, so it should be stored in a tightly sealed container. Additionally, it should be kept away from extremely hot or cold places, and it is safe to store it at room temperature between 1 and 30 degrees Celsius.

Appearance

Yellow oblong film-coated tablet

Package unit

28 tablets/box [(7 tablets/PTP x 4)], 30 tablets/box [(10 tablets/PTP x 3)]