Pachycombi Tablet 10/100 mg

Adult dosage

This medication can be administered as 1 tablet once daily to patients receiving 100 mg of sitagliptin and 10 mg of dapagliflozin, regardless of meals. The tablet should be swallowed whole.

This medication contains sitagliptin and dapagliflozin and is used for diabetes treatment. First, the sitagliptin component may rarely cause serious allergic reactions, so if symptoms such as rash, itching, or difficulty breathing occur, discontinue use immediately and consult a doctor. Additionally, pancreatitis, which is inflammation of the pancreas, has been reported, so if symptoms such as abdominal pain, vomiting, or nausea occur, seek medical attention immediately. Next, the dapagliflozin component may cause dehydration leading to low blood pressure, so caution is especially necessary for elderly patients with reduced kidney function or those on diuretics. If symptoms of dehydration or low blood pressure occur while taking this medication, inform your doctor. Furthermore, dapagliflozin may cause serious metabolic abnormalities such as acute pancreatitis and diabetic ketoacidosis, so if symptoms such as abdominal pain, vomiting, difficulty breathing, or fatigue occur, visit a medical institution immediately. This medication can increase the risk of urinary and genital infections, so if infection symptoms occur, seek prompt treatment, especially in patients with a history of infections. Occasionally, severe infections can occur in the perineum; therefore, if swelling, pain, or redness occurs in the perineum, consult a doctor immediately. This medication should not be used in patients with certain genetic disorders, type 1 diabetes, or those undergoing dialysis, and should be avoided by women who are pregnant or breastfeeding. There is a risk of hypoglycemia while taking this medication, so if taken in conjunction with other hypoglycemic agents such as insulin or sulfonylureas, blood sugar changes should be closely monitored, and dose adjustments may be necessary. Finally, this medication has not established its safety and efficacy in children under 18 years of age and should not be used in this population. It is important to consult healthcare professionals immediately if any abnormal symptoms occur while taking this medication.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, paleness, severe rash with fever, blisters, skin peeling, oral/ocular mucosal pain, dyspnea or difficulty breathing, asthma attack, coughing with fever and respiratory abnormalities, jaundice (yellowing of the skin or eyes), severe lethargy, sudden and extreme headache, lightning headache, seizures, confusion, visual disturbances, paralysis, urination changes

Mild side effects

Hypoglycemia, reduced blood volume, dry mouth, constipation, back pain, polyuria, nocturia, vulvar itching, genital itching, increased hematocrit, decreased renal creatinine clearance at the start of treatment, dyslipidemia, elevated blood creatinine, elevated blood urea, weight loss, dizziness, hypersensitivity, dyspepsia, nausea, diarrhea, vomiting, weakness, pain, hunger, itching, urticaria, cold sweat, arthralgia, musculoskeletal pain

This medication is sensitive to air and moisture, so it should be stored in a tightly sealed container. It is best stored at room temperature between 1 degree and 30 degrees Celsius.

Appearance

Yellow rectangular film-coated tablet

Package unit

28 tablets/box [7 tablets/PTP*4], 30 tablets/box [10 tablets/PTP*3]