Ponuvia Tablet 10/100 Milligrams

Adult dosage

This medication may be administered to patients taking sitagliptin 100 mg and dapagliflozin 10 mg at a dosage of one tablet once daily, regardless of meals. The tablet should be swallowed whole.

This medication may cause allergic reactions, so if symptoms such as skin rash, difficulty breathing, or swelling of the face or neck occur, you should stop taking it immediately and consult a doctor. This medication can cause a serious pancreatic condition called pancreatitis, so if you experience symptoms like abdominal pain, nausea, vomiting, or fever while taking it, inform your doctor immediately. Depending on the type of diabetes, this medication should not be taken; patients with type 1 diabetes or diabetic ketoacidosis should not use this medication. Patients with lactose intolerance or specific genetic conditions should avoid this medication due to the ingredients it contains. Patients with severely impaired renal function or undergoing dialysis should avoid taking this medication, and those with slightly reduced renal function may require dose adjustments. This medication may lead to symptoms associated with reduced fluid volume, such as dehydration or low blood pressure, so older adults or those taking diuretics should closely monitor their blood pressure and hydration status. There is a risk of hypoglycemia, so when taken with insulin or sulfonylurea medications, blood sugar should be checked frequently, and the dosage of these medications may need to be adjusted if necessary. The risk of genital and urinary tract infections may increase, hence treatment should be sought immediately if infection symptoms occur, and patients with a history of recurrent infections should be especially cautious. Pregnant or breastfeeding women are advised against taking this medication, and it should be discontinued immediately if pregnancy is confirmed. This medication is not recommended for use in children under 18 years old as safety and efficacy have not been established. In case of overdose, there is no specific antidote, but appropriate treatment should be administered based on symptoms, with monitoring in a hospital if necessary. Caution is advised when driving or operating machinery due to the risk of hypoglycemia, so one should be careful when symptoms occur.

Serious side effects

Hives, severe swelling (edema), anaphylaxis, angioedema, severe skin reactions (Stevens-Johnson syndrome, exfoliative skin disease, bullous pemphigoid), acute pancreatitis, hemorrhagic or necrotizing pancreatitis, severe hypoglycemia, acute kidney failure, deterioration of kidney function, ketoacidosis (including diabetic ketoacidosis), urosepsis, pyelonephritis, fulminant necrosis (Fournier's gangrene), severe headache, seizures, altered consciousness, visual disturbances,

Mild side effects

• Headache
• upper respiratory infection
• nasopharyngitis
• constipation
• dry mouth
• back pain
• urinary pain
• polyuria
• nocturia
• itching of the vulva

This medication should be stored in a tightly closed container to prevent exposure to air or moisture. Additionally, it is advisable to store it at room temperature between 1 and 30 degrees Celsius.

Appearance

Yellow, rectangular film-coated tablet

Package unit

28 tablets/box [(7 tablets/PTP x 4)], 30 tablets/box [(10 tablets/PTP x 3)]