Sitagliptin and Metformin Tablets 50/1000 mg

Adult dose

The daily maximum recommended dosage for each component is determined within the range of sitagliptin 100 mg and metformin 2000 mg. Generally taken twice a day with meals, the dosage should be gradually increased to reduce gastrointestinal adverse reactions attributed to metformin. 1. Patients not treated with metformin: The initial dosage is this medication 50/500 mg taken twice a day, 1 tablet per dose, with the possible increase to 50/1000 mg, 1 tablet twice a day.

This medication can cause severe allergic reactions; therefore, if symptoms such as skin rashes or shortness of breath occur within 3 months of administration, immediately stop use and consult a physician. This medication may induce pancreatitis, so notify healthcare providers if symptoms such as abdominal pain, vomiting, or fever occur. This medication should not be used in patients with severely impaired kidney function or acute illness. Before undergoing surgery or tests involving iodine contrast, temporary cessation of this medication is necessary, and it should be resumed only after confirming normal kidney function. Women who are pregnant or may become pregnant, as well as nursing mothers, are advised not to take this medication. Maintain regular meals and exercise while taking this medication, and have regular checks of blood sugar and kidney function. Hypoglycemia may occur, particularly when used with insulin or other antidiabetic agents, so extra caution is advised. This medication is not recommended for patients with liver dysfunction, and alcohol consumption should be avoided due to the increased risk of lactic acidosis. If severe joint pain or blisters on the skin develop during treatment, promptly consult a healthcare provider. Consult healthcare providers immediately if sudden muscle pain, fatigue, or shortness of breath occurs during treatment. In case of overdose, immediate treatment is necessary, as some components may be removed through hemodialysis. Elderly patients may have decreased kidney function; thus, dose adjustments and regular kidney function monitoring are necessary. This medication may interact with other drugs, so inform your doctor or pharmacist about any other medications being taken.

Serious side effects

Hives, severe swelling (angioedema), anaphylaxis, rash, exfoliative skin diseases such as Stevens-Johnson syndrome, acute pancreatitis (hemorrhagic or necrotizing), acute renal failure, shortness of breath, severe and disabling joint pain, blistering dermatosis, elevated liver enzymes, thrombocytopenia, severe hypoglycemia, dyspnea, unstable angina, acute renal failure, severe lactic acidosis, hypoglycemia, acute and severe hypersensitivity reactions (anaphylaxis

Mild side effects

• Diarrhea
• nausea
• vomiting
• abdominal pain
• upper respiratory infection
• nasopharyngitis
• headache
• hypoglycemia
• constipation
• muscle pain

Store this medication in a tightly sealed container to prevent air or moisture exposure, preferably at room temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness for a longer period.

Appearance

Pink oval film-coated tablet

Package unit

30 tablets/box [(10 tablets/PTP x 3)]