Dangi Ja Nookombi Tablets 50/500 mg

Adult dose

This medication is typically taken twice daily with food, and the dosage is gradually increased to reduce gastrointestinal adverse effects from metformin. 1. For patients not previously treated with metformin: The initial dose is 50/500 mg taken twice daily, with the possibility of increasing to 50/1000 mg. 2. For patients already on metformin: The recommended initial dose is sitagliptin 50 mg taken twice daily (total daily amount 100 mg) along with the current metformin dosage.

This medication contains sitagliptin and metformin and is used for treating diabetes. First, there is a risk of severe allergic reactions within the first three months of administration, so caution is needed. If symptoms such as rash, shortness of breath, or swelling of the face or neck occur, discontinue use immediately and consult a doctor. This medication may cause acute pancreatitis, which is a serious inflammation of the pancreas; if symptoms such as abdominal pain, nausea, or vomiting occur, inform healthcare personnel immediately. The metformin component can cause a rare but serious metabolic disturbance called lactic acidosis, so patients with severe dehydration, infections, heart diseases, liver diseases, or impaired renal function should not take this medication. Patients with moderate or more severe renal impairment, acute heart failure, or those scheduled for tests using iodine contrast agents should not take this medication. It is not safe for use during pregnancy or breastfeeding, or in children and adolescents under 18 years, as safety has not been established. During treatment, it is important to regularly monitor kidney function and blood tests, as vitamin B12 levels may need to be checked because of the risk of deficiency. Also, this medication may induce hypoglycemia, so caution is advised when skipping meals or engaging in vigorous exercise, and be aware that the risk of hypoglycemia may increase when taking it together with other hypoglycemic agents such as insulin or sulfonylureas. Alcohol consumption can increase the risk of lactic acidosis, so avoid excessive drinking while on this medication. Before and after surgery, discontinue this medication for a period of time and restart it only after the patient’s condition stabilizes. Rarely, this medication can cause severe joint pain or the formation of blisters on the skin, so if such symptoms occur, inform a doctor immediately and seek treatment. Finally, regular monitoring of blood sugar and kidney function is crucial during treatment, and immediately consult healthcare personnel if unusual symptoms arise.

Serious side effects

Hives, severe swelling (angioedema), anaphylaxis, rash, exfoliative skin disease (including Stevens-Johnson syndrome), severe skin reactions, acute pancreatitis (including fatal/non-fatal hemorrhagic or necrotizing), acute renal failure, acute deterioration of kidney function, shortness of breath, unstable angina, acute heart failure, severe joint pain, bullous pemphigoid, thrombocytopenia, liver abnormalities (elevated liver enzymes, potential for jaundice), severe swelling, hypoglycemia

Mild side effects

• Diarrhea
• upper respiratory infection
• headache
• nasopharyngitis
• constipation
• vomiting
• joint pain
• muscle pain
• limb pain
• back pain

This medication should be stored in a tightly sealed container to prevent air and moisture from entering, and it is safe to keep it at a temperature between 1 to 30 degrees Celsius. Proper storage will help maintain the medicine's effectiveness for a longer period.

Appearance

Bright pink oval film-coated tablet

Package unit

30 tablets/box [(10 tablets/PTP x 3)]