Sitagliptin M Tablet 50/1000 mg (Sitagliptin Hydrochloride Hydrate, Metformin Hydrochloride Colloidal Silicon Dioxide)

Adult dose

This medication is generally taken twice daily with food, and the dosage should be gradually increased to reduce gastrointestinal side effects caused by metformin. 1. For patients currently not on metformin therapy: The initial dosage is to take 50/500 mg of this medication twice a day, 1 tablet each time, and it can be increased to 50/1000 mg, 1 tablet twice a day. 2. For patients receiving metformin therapy:

This medication is a diabetes treatment that contains both sitagliptin and metformin, helping to control blood glucose. First, when taking this medication, serious allergic reactions may occur, so if symptoms such as skin rash, hives, or difficulty breathing appear, stop taking it immediately and consult a doctor. Additionally, there is a risk of pancreatitis, which is inflammation of the pancreas, so if there is abdominal pain, vomiting, or severe abdominal pain, immediate treatment should be sought. The metformin component in this medication can rarely cause a serious condition called lactic acidosis, which can become dangerous due to excessive lactate accumulation in the body, so if symptoms such as shortness of breath, muscle pain, fatigue, or abdominal pain appear, inform medical personnel immediately. This medication should not be taken by individuals with poor kidney function, acute infections, severe dehydration, or unstable heart function, and administration should be temporarily suspended if surgery is imminent or if undergoing exams using radiopaque agents. It is also safe for pregnant or breastfeeding women to avoid using this medication. While taking this medication, regular kidney function and blood tests should be performed, and vitamin B12 levels may decrease, so supplementation may be necessary if needed. Also, if used in combination with other diabetes medications or insulin, hypoglycemia may occur, so blood glucose changes should be carefully monitored, and appropriate action should be taken if symptoms arise. Excessive alcohol consumption can increase the risk of side effects from this medication, so it is advisable to avoid it. Finally, if sudden joint pain or blisters on the skin occur while taking this medication, it is important to inform a doctor to receive appropriate treatment.

Serious side effects

Hives, severe hypersensitivity reactions (anaphylaxis, angioedema, Stevens-Johnson syndrome), acute pancreatitis, lactic acidosis, acute renal failure, shortness of breath, unstable angina, dermatitis, blistering dermatitis, thrombocytopenia, increased liver enzyme levels, fatal hemorrhagic pancreatitis, severe edema, acute renal failure, severe hypoglycemia, severe joint pain accompanied with severe disability, severe skin reactions (severe rashes, blisters, peeling skin, mouth/eye lesions)

Mild side effects

• Diarrhea
• nausea
• vomiting
• abdominal pain
• upper respiratory infection
• nasopharyngitis
• headache
• hypoglycemia
• constipation
• asthenia

This medication should be stored in a tightly sealed container that is well-ventilated, and it is best to keep it at room temperature between 1 degree and 30 degrees Celsius. Proper storage like this helps maintain the medication's efficacy and prevents deterioration.

Appearance

Pink oval film-coated tablet

Package unit

30 tablets/box [(10 tablets/PTP x 3)]