Sitagliptin M 50/500 mg Tablet (Sitagliptin Hydrochloride Monohydrate, Metformin Hydrochloride with Colloidal Silicon Dioxide)

Adult dose

This medication is generally taken twice daily with food while gradually increasing the dosage to reduce gastrointestinal side effects associated with Metformin. 1. For patients who are not currently treated with Metformin: Take this medication 50/500 mg twice daily, 1 tablet at a time, and it can be escalated to 50/1000 mg twice daily, 1 tablet at a time. 2. For patients currently receiving Metformin treatment:

This medication may cause severe allergic reactions after administration, so if any allergic symptoms are suspected, stop use immediately and consult a physician. Additionally, acute pancreatitis may occur, so if symptoms such as abdominal pain or vomiting appear, inform medical personnel promptly. Patients with severely reduced kidney function or in situations with a risk of acute renal failure should not use this medication, and kidney function tests should be performed regularly. Patients with acute cardiovascular diseases such as heart failure, myocardial infarction, or sepsis should also avoid use. Particularly, prior to and after examinations using iodinated contrast agents, the use of this medication should be temporarily suspended, and reinstitution should be based on kidney function checks. It is safe for women who are pregnant or breastfeeding to avoid using this medication. Patients with irregular meals or those engaging in intense physical activity should be cautious about the risk of hypoglycemia when used in conjunction with other hypoglycemic agents. This medication may cause side effects such as gastrointestinal disturbances, diarrhea, headache, upper respiratory tract infections, so consult a physician if symptoms are severe. Alcohol consumption can increase the risk of lactic acidosis, so excessive drinking should be avoided during treatment. Prior to and after surgery, administration should be stopped for a period of time and should only be restarted after the patient's condition is stabilized. Regular monitoring of kidney function and vitamin B12 levels through blood tests is important, and appropriate supplementation is required if vitamin B12 deficiency is suspected. If symptoms of hypoglycemia occur during treatment, immediate appropriate measures must be taken, especially for elderly patients or those in poor nutritional status. If severe joint pain or skin abnormalities occur, inform medical personnel immediately, and if necessary, drug discontinuation and specialist consultation are required.

Serious side effects

• Hives
• severe swelling (angioedema)
• anaphylaxis
• rash
• Stevens-Johnson syndrome
• exfoliative skin conditions
• acute pancreatitis
• acute renal failure
• dyspnea
• unstable angina

Mild side effects

• Upper respiratory tract infections
• nasopharyngitis
• constipation
• vomiting
• headache
• muscle pain
• limb pain
• back pain
• pruritus
• thrombocytopenia

Store this medication in a tightly closed container to prevent air and moisture exposure. It is advisable to maintain a storage temperature between 1 and 30 degrees Celsius at room temperature. This will ensure the efficacy is not altered and can be used safely.

Appearance

Bright pink oval film-coated tablet

Package unit

30 tablets/box [(10 tablets/PTP x 3)]