Sitagliptin M 50/850 mg tablet (Sitagliptin hydrochloride monohydrate, Metformin hydrochloride, colloidal silicon dioxide)

Adult dose

This medication is generally taken twice daily with food, gradually increasing the dose to reduce gastrointestinal adverse reactions related to metformin. 1. For patients not currently being treated with metformin: The initial dose is 1 tablet (50/500 mg) taken twice daily, and it can be increased to 50/1000 mg. 2. For patients currently on metformin: The recommended initial dosage is sitagliptin 50 mg taken twice daily (total daily dosage 100 mg) with existing metformin dosing.

This medication contains sitagliptin and metformin, and there are several precautions to consider while taking it. First, this medication may cause allergic reactions; therefore, if symptoms such as a skin rash, difficulty breathing, or swelling of the face or neck occur, discontinue use immediately and consult with a physician. In addition, serious side effects such as acute pancreatitis, which is inflammation of the pancreas, have been reported. If abdominal pain, nausea, or vomiting occurs during treatment, notify medical personnel immediately. The metformin component may rarely cause lactic acidosis, a serious metabolic abnormality, so if sudden muscle pain, fatigue, difficulty breathing, or abdominal pain occurs, immediate treatment is necessary. This medication should not be administered to patients with moderate or severe renal impairment or severe hepatic dysfunction. Furthermore, treatment with this drug should be temporarily suspended before and after surgery or examinations using iodinated contrast media, and it should be resumed only after normal renal function is confirmed. It is recommended that this medication not be used in pregnant women or breastfeeding mothers. Elderly patients may have decreased renal function, thus regular renal function checks are necessary, and dosage adjustment may be required. During treatment with this medication, alcohol consumption should be avoided, and treatment should be discontinued and a physician consulted in cases of sudden dehydration, severe infections, or cardiovascular problems. When taken in conjunction with other drugs that lower blood sugar, hypoglycemic symptoms may occur, so it is crucial to monitor symptoms closely and adjust drug dosage as necessary. Finally, it is important to have regular checks of blood sugar, renal function, and blood tests to monitor for adverse reactions during treatment with this medication.

Serious side effects

• Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, pallor (severe allergic reaction)
• Severe rash with high fever, blisters, skin peeling, pain of oral/ocular mucosa (severe skin abnormal reaction)
• Difficulty breathing or shortness of breath, asthma attacks, cough with fever accompanying respiratory abnormalities
• Yellowing of skin or eyes (jaundice), profound fatigue (liver abnormalities)
• Sudden and severe headache, lightning-like headache

Mild side effects

• Diarrhea
• nausea
• vomiting
• abdominal pain
• upper respiratory infections
• nasopharyngitis
• headache
• hypoglycemia
• constipation
• weakness

This medication should be stored in a tightly closed container to prevent air exposure and kept at room temperature between 1°C and 30°C. Proper storage will help maintain the medication's effectiveness for a longer period.

Appearance

Pink oval film-coated tablet

Package unit

30 tablets/box [(10 tablets/PTP x 3)]