Sitagliptin 50/500 mg Tablets (Sitagliptin Hydrochloride Hemihydrate, Metformin Hydrochloride Colloidal Silicon Dioxide)

Adult dose

This medication is typically taken twice daily with food, and to reduce gastrointestinal adverse reactions caused by metformin, the dosage should be gradually increased. 1. For patients not currently treated with metformin: The initial dosage of this medication is 50/500 mg, taken as one tablet twice a day, which may be increased to 50/1000 mg, taken as one tablet twice a day. 2. For patients who are receiving treatment with metformin:

This medication can cause severe allergic reactions, although rare, so if symptoms such as rash or difficulty breathing occur, it should be discontinued immediately and a doctor should be consulted. Also, as pancreatitis, a condition characterized by inflammation of the pancreas, may occur, patients should visit the hospital immediately if symptoms such as abdominal pain, vomiting, or fever appear after taking the medication. This medication should not be administered to patients with significantly impaired renal function, acute heart failure, severe infection, or dehydration; it should also be temporarily discontinued before and after surgery. Patients with poor liver function, or women who are pregnant or breastfeeding, should not use this medication for safety reasons. While taking this medication, patients should be cautious of symptoms of hypoglycemia, especially when taken in conjunction with other hypoglycemic agents, as the risk of hypoglycemia may increase, necessitating frequent blood sugar checks and immediate action upon symptom onset. This medication may commonly cause side effects such as gastrointestinal disturbances, diarrhea, nausea, and vomiting, so it is advisable to consult a doctor if these symptoms are severe. Alcohol consumption may increase the risk of lactic acidosis, a side effect of this medication, so excessive drinking should be avoided during use. Additionally, regular kidney function and blood tests should be conducted to monitor the patient's condition, and vitamin B12 levels may decrease, so supplementation may be necessary if required. If sudden weight loss, decreased appetite, joint pain, rash, or blistering skin conditions occur during treatment with this medication, patients should inform their healthcare provider immediately. Lastly, when administering this medication to the elderly, careful monitoring of renal function should be conducted, and it is safest to start at the minimum dose.

Serious side effects

Hives, severe swelling (angioedema), anaphylaxis, chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, skin peeling, pain in oral/eye mucosa, acute pancreatitis, severe dermatitis (such as Stevens-Johnson syndrome), acute renal failure, severe swelling, increased blood pressure, jaundice (yellowing of the skin or eyes), liver abnormalities, sudden and severe headache, thunderclap headache, seizures

Mild side effects

• Diarrhea
• upper respiratory infection
• headache
• nausea
• vomiting
• abdominal pain
• nasopharyngitis
• constipation
• muscle pain
• limb pain

This medication should be stored in a tightly sealed container to prevent air or moisture from entering, and it is best to store it at room temperature between 1 degree and 30 degrees Celsius. Proper storage will help maintain the medication's efficacy for a longer period.

Appearance

Bright pink oval film-coated tablet

Package unit

30 tablets/box [(10 tablets/PTP x 3)]