Esmet Tablet 50/850 mg

Adult dose

This medication is generally taken twice daily with food, and the dosage should be gradually increased to reduce gastrointestinal side effects caused by Metformin. 1. Patients not currently treated with Metformin: This medication 50/500 mg is taken twice daily at 1 tablet at a time, and may be increased to 50/1000 mg taken twice daily at 1 tablet at a time. 2. Patients being treated with Metformin: Sitagliptin

This medication may cause severe allergic reactions; if symptoms such as skin rash, difficulty breathing, or swelling of the face or tongue appear within three months after administration, usage should be immediately discontinued and medical advice should be sought. It can induce serious pancreatic inflammation known as pancreatitis; if symptoms such as abdominal pain, vomiting, or fever occur, discontinue use immediately and inform healthcare professionals. Patients with severely impaired kidney function, acute heart failure, serious infections, dehydration, or severe liver dysfunction should not use this medication. It is not safe for women who are pregnant or breastfeeding, and the safety in pediatric patients under 18 years old has not been established. During treatment, kidney function should be regularly monitored to detect deterioration early and take appropriate measures. Excessive alcohol consumption may result in lactic acidosis, a dangerous condition occurring alongside this medication, so alcohol should be avoided while taking it. Patients undergoing surgery should stop taking this medication 48 hours before the procedure and resume only after checking that kidney function is normal post-surgery. This medication lowers blood sugar, thus when used with other blood sugar-lowering agents or insulin, the risk of hypoglycemia may increase; careful monitoring of blood sugar levels is essential. Particularly in elderly patients, malnourished individuals, or patients engaging in strenuous exercise, the risk of hypoglycemia is higher, necessitating caution. Patients taking this medication may experience gastrointestinal disturbances such as diarrhea, nausea, vomiting, and abdominal pain; if these symptoms are severe, medical consultation is advised. If a rash, severe joint pain, or bullous dermatosis occurs during treatment, immediate medical attention is required. Additionally, this medication may interact with certain drugs, so patients taking other medications should inform their healthcare providers. In case of overdose, immediate medical assistance should be sought, and blood dialysis may be necessary, thus prompt action is important.

Serious side effects

Hives, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, pain in oral/ocular mucosa, shortness of breath or difficulty breathing, asthma attack, cough accompanied by fever and respiratory distress, yellowing of skin or eyes (jaundice), severe lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, urination issues

Mild side effects

• Diarrhea
• upper respiratory infection
• headache
• nausea
• vomiting
• abdominal pain
• nasopharyngitis
• constipation
• muscle pain
• limb pain

This medication should be stored in a tightly sealed container to prevent air and moisture ingress. It is best kept at room temperature between 1 to 30 degrees Celsius.

Appearance

Pink oval film-coated tablet

Package unit

30 tablets/box [(10 tablets/PTP x 3)]