Janualin Duo Tablet 50/500 mg

Adult dose

In diabetes therapy, the dosage of this medication should be determined considering the patient’s current treatment regimen, efficacy, and tolerability, not exceeding a dose of sitagliptin 100 mg and metformin 2000 mg. This medication is generally taken twice daily with food, and the dosage should be gradually increased to minimize gastrointestinal adverse effects caused by metformin. 1. Patients not receiving metformin: Initial dosage.

This medication contains two components used for diabetes treatment: sitagliptin and metformin. One of the most important precautions while taking this medication is the risk of hypersensitivity reactions. Serious allergic reactions such as skin rashes, hives, and breathing difficulties may occur after taking this medication, so if these symptoms arise, discontinue use immediately and consult a physician. Moreover, this medication may cause pancreatitis, an inflammation of the pancreas, so if symptoms such as abdominal pain, nausea, vomiting, or fever appear while taking it, seek immediate medical attention. The metformin component can lead to lactic acidosis, a rare but very serious side effect, characterized by fatigue, difficulty breathing, or abdominal pain. If these symptoms occur, discontinue use immediately and seek emergency treatment. This medication is not administered to patients with severely reduced kidney function, severe infections, acute heart failure, or acute myocardial infarction. It is also not used in pregnant or nursing women. Regular monitoring of kidney function is essential during treatment, and the medication should be temporarily halted in cases of dehydration or severe vomiting, diarrhea, etc. This medication may cause hypoglycemia, particularly when taken with insulin or sulfonylureas, so blood sugar levels should be frequently checked, and immediate action should be taken if symptoms occur. Furthermore, excessive alcohol consumption should be avoided while taking this medication, and in cases of upcoming surgery, the medication should be discontinued 48 hours prior, resuming only after kidney function has returned to normal. Blistering on the skin or severe joint pain may occur, so inform a physician immediately and seek treatment if these symptoms arise. Finally, the safety and efficacy of this medication have not been confirmed for children and adolescents under 18 years of age, so it is not used in this population. Regular blood tests and kidney function assessments are of utmost importance while undergoing treatment to check for any abnormalities.

Serious side effects

Hives, severe swelling (angioedema), anaphylaxis, chest tightness, difficulty breathing, severe allergic reactions, severe skin reactions (Stevens-Johnson syndrome, exfoliative skin disease, rash, vasculitis), acute pancreatitis (hemorrhagic or necrotizing pancreatitis, fatal/non-fatal), liver abnormalities (elevated liver enzymes, jaundice), respiratory problems (dyspnea, asthma attacks), severe neurological symptoms (severe headache, confusion, seizures,

Mild side effects

• Diarrhea
• upper respiratory tract infection
• headache
• nausea
• vomiting
• abdominal pain
• nasopharyngitis
• constipation
• weakness
• thrombocytopenia

This medication should be stored in a tightly closed container that is well-ventilated, at room temperature between 1 and 30 degrees Celsius. Proper storage will help maintain the medication's effectiveness for a longer time.

Appearance

Bright pink oval film-coated tablet

Package unit

30 tablets/box [(10 tablets/PTP x 3)]