Janualin Duo Tablets 50/850 mg

Adult dose

This drug is generally taken twice a day with food, and the dosage is gradually increased to reduce gastrointestinal adverse reactions caused by metformin. 1. Patients who are not currently treated with metformin: - The initial dose of this drug 50/500 mg is taken as 1 tablet twice daily. - If needed, the dose may be increased to this drug 50/1000 mg taken as 1 tablet twice daily. 2

This drug contains sitagliptin and metformin, both of which are used in the treatment of diabetes. Firstly, sitagliptin can rarely cause serious allergic reactions, so if symptoms such as skin rash, hives, or difficulty breathing occur, the patient should stop taking the medication immediately and seek medical attention. Additionally, there is a risk of acute pancreatitis, which can cause inflammation of the pancreas, so if abdominal pain, vomiting, or severe abdominal pain occurs, a medical facility should be visited promptly. Metformin can rarely cause a serious metabolic abnormality called lactic acidosis, which is a dangerous condition that occurs when lactic acid accumulates excessively in the body. This condition is particularly likely to occur in patients with poor kidney function, liver dysfunction, severe infections, or dehydration. This drug should not be administered to patients with moderate to severe decreased kidney function, acute heart failure, acute myocardial infarction, sepsis, or other acute diseases. Furthermore, the use of this drug should be temporarily discontinued before and after undergoing examinations that use radiologic contrast agents due to the risk of worsening kidney function and lactic acidosis. It is also not recommended for pregnant women or nursing mothers. Patients should be vigilant for hypoglycemic symptoms while taking this medication, especially if it is taken in conjunction with insulin or sulfonylurea, as the risk of hypoglycemia is heightened. Moreover, this drug can occasionally cause gastrointestinal disturbances (diarrhea, nausea, vomiting, abdominal pain), headaches, and upper respiratory infections. If symptoms are severe, patients should consult their doctor. Regular kidney function and blood tests should be conducted before and during treatment, and vitamin B12 levels should also be periodically checked. Alcohol can increase the risk of lactic acidosis while taking this medication, so excessive drinking should be avoided. If eating becomes difficult due to surgery or significant illness, the use of this drug should be temporarily suspended and resumed after recovery. Finally, if severe joint pain or blisters on the skin occur while taking this medication, the patient should immediately inform their doctor. This drug requires careful monitoring and regular testing based on the patient's condition, and medical personnel should be consulted immediately if abnormal symptoms occur.

Serious side effects

• Hives
• angioedema
• anaphylaxis
• rash
• Stevens-Johnson syndrome
• severe allergic reactions
• acute pancreatitis
• acute renal failure
• difficulty breathing
• unstable angina

Mild side effects

• Diarrhea
• nausea
• vomiting
• abdominal pain
• upper respiratory infections
• nasopharyngitis
• headache
• hypoglycemia
• myalgia
• limb pain

This medication should be stored in an airtight container to prevent exposure to air or moisture. It is advisable to maintain a storage temperature between 1 degree and 30 degrees Celsius at room temperature. Proper storage will help maintain the drug's efficacy and safety.

Appearance

Pink oval film-coated tablet

Package unit

30 tablets/box [(10 tablets/PTP x 3)]