Acytamet Tablet 50/500 mg

Adult dose

Generally, this medication is administered twice daily with food, and to reduce gastrointestinal adverse reactions caused by metformin, the dosage should be gradually increased. 1. For patients not currently receiving treatment with metformin: Initial dosage of this medication is 50/500 mg taken twice daily, 1 tablet at a time, and the dosage can be increased to 50/1000 mg taken twice daily, 1 tablet at a time. 2. For patients on metformin treatment:

This medication contains both sitagliptin and metformin for diabetes treatment. Firstly, sitagliptin can rarely cause serious allergic reactions, so patients should be cautious of symptoms of hypersensitivity during the first three months. Additionally, there is a risk of developing a serious pancreatic disease called pancreatitis, so if symptoms such as abdominal pain or vomiting occur, patients should consult a doctor immediately. Metformin can result in lactic acidosis, a rare but fatal metabolic complication, thus it should not be administered to patients with reduced kidney function or liver disease. Specifically, it should not be used in cases of acute kidney failure, dehydration, severe infections, or cardiovascular issues. This medication is not to be administered to children under 18 years of age or to pregnant or nursing women. For the elderly, dosage adjustment and regular kidney function monitoring are necessary due to potentially decreased kidney function. Patients should be vigilant for hypoglycemia symptoms during treatment, especially when taken with other hypoglycemic agents or insulin, as the risk of hypoglycemia may increase. Moreover, excessive alcohol intake might elevate the risk of lactic acidosis and should be avoided. Before and after examinations using iodine-based contrast agents, this medication should be temporarily discontinued, and it should be resumed only after confirming normal kidney function. For patients undergoing surgery, the medication should be halted 48 hours before surgery and can be restarted once kidney function has recovered post-surgery. While taking this medication, it is advisable to have regular checks of blood sugar, kidney function, liver function, and hematological tests, and to monitor vitamin B12 levels. If symptoms such as skin rashes, hives, difficulty breathing, severe abdominal pain, vomiting, severe joint pain, or blistering skin conditions appear, patients should inform their doctor immediately. This medication may interact with other drugs, so it is crucial to inform healthcare providers of any other medications being taken, especially those that could affect kidney function. Finally, it is essential to maintain a balanced diet and exercise routine while taking this medication, along with consistent monitoring of blood sugar and physical condition.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, pallor (severe allergic reaction), fever with severe rash, blisters, skin peeling, pain in mucous membranes of mouth/eyes (severe skin reaction), shortness of breath or difficulty breathing, asthma attacks, cough with fever, skin or eyes turning yellow (jaundice), extreme fatigue (liver dysfunction), sudden and very severe headaches

Mild side effects

• Diarrhea
• upper respiratory infection
• headache
• nausea
• vomiting
• abdominal pain
• nasopharyngitis
• constipation
• muscle pain
• limb pain

This medication should be stored in a tightly closed container to prevent air ingress and should be kept at a temperature between 1 and 30 degrees Celsius. This will help maintain its efficacy and prevent degradation.

Appearance

Bright pink oval film-coated tablet

Package unit

30 tablets/box [(10 tablets/PTP x 3)]