Nexgliptin Duo Tablet 50/1000 mg

Adult dose

This medication is generally taken twice daily with food, and the dosage is gradually increased to reduce gastrointestinal adverse reactions caused by metformin. The initial dose is determined based on the patient's current treatment regimen. 1. For patients not currently being treated with metformin: Take this drug 50/500 mg twice daily, 1 tablet at a time, and it can be increased to 50/1000 mg twice daily, 1 tablet at a time.

This medication may cause hypersensitivity reactions; if symptoms of allergy, skin rash, or difficulty breathing occur, discontinue use immediately and consult a doctor. Also, if symptoms of acute pancreatitis such as severe abdominal pain, nausea, or vomiting appear, cease medication immediately and inform healthcare personnel. This drug should not be used in patients with moderate or severe renal impairment or in states at risk of acute kidney failure, and kidney function should be regularly monitored for normalcy. Administration should also be avoided in patients with acute or unstable heart failure, severe infections, cardiovascular collapse, and in cases where iodine contrast agents are used during certain tests. It is advised not to use this medication during pregnancy or in women of childbearing potential, as well as in nursing mothers. Patients with irregular meals, malnutrition, engaging in vigorous exercise, or those using other medications that may cause hypoglycemia should exercise caution. This drug can cause a rare but serious side effect called lactic acidosis, so if symptoms like muscle pain, weakness, difficulty breathing, or abdominal pain occur, contact healthcare personnel immediately. Additionally, excessive alcohol consumption may increase the risk of lactic acidosis, so it is best to avoid. Due to the risk of hypoglycemia, the changes in blood sugar should be closely monitored when using this medication in conjunction with blood sugar-lowering agents or insulin, and the dosage of other medications should be adjusted if necessary. Before and after surgery, this medication should be discontinued for a certain period, resuming only after the patient's condition has stabilized and kidney function is confirmed to be normal. Routine blood tests and kidney function checks should be conducted while on this medication, and periodic checks of vitamin B12 levels are recommended. If blisters or rash appear on the skin, inform a doctor immediately, and precaution should be taken in cases of severe joint or muscle pain. This medication is not used in children and adolescents as its safety and efficacy have not been confirmed. In the case of overdose, inform healthcare personnel immediately and receive appropriate treatment, including blood dialysis if necessary.

Serious side effects

Hives, severe swelling (angioedema), severe allergic reactions, anaphylaxis, angioedema, Stevens-Johnson syndrome, exfoliative dermatitis, severe rash and blistering with high fever, skin peeling, oral/ocular mucosal pain, severe skin adverse reactions, difficulty breathing, dyspnea, asthma attacks, respiratory disturbances accompanied by cough and fever, liver abnormalities (jaundice), jaundice of the skin or eyes, sudden and severe headache, thunderclap headache

Mild side effects

• Diarrhea
• nausea
• vomiting
• abdominal pain
• upper respiratory tract infections
• nasopharyngitis
• headache
• hypoglycemia
• constipation
• muscle pain

This medication should be stored in a tightly sealed container to protect it from air and moisture. Additionally, it is best stored at room temperature, between 1 and 30 degrees Celsius, avoiding extremes of heat or cold.

Appearance

Pink oval film-coated tablet

Package unit

30 tablets/box [(10 tablets/PTP x 3)]