Sitaren Duo Tablet 50/500 mg

Adult dose

This medication is generally taken twice daily with food, and the dose is gradually increased to minimize gastrointestinal adverse reactions due to metformin. 1. For patients not currently receiving metformin: This medication at 50/500 mg is taken as one tablet twice daily, and can be increased to 50/1000 mg as one tablet twice daily. 2. For patients receiving metformin treatment:

This medication contains sitagliptin and metformin and is used in the treatment of diabetes. When taking this medication, severe allergic reactions may occur, so if symptoms such as skin rash, urticaria, difficulty breathing, or swelling of the face or neck appear, you should stop taking it immediately and inform a doctor. Serious pancreatic inflammation known as pancreatitis may occur, so immediate consultation with healthcare providers is necessary if symptoms such as abdominal pain, nausea, vomiting, or fever occur. Patients with severely impaired kidney function, acute illnesses, heart failure, myocardial infarction, sepsis, or those with similar conditions should not use this medication. Administration should be temporarily suspended before and after examinations using iodine contrast agents, and should only be resumed after confirming normal kidney function. Pregnant women, women who may become pregnant, and nursing mothers should not use this medication. Exercise caution if experiencing irregular meals, nutritional deficiencies, or intense physical activity as this may increase the risk of hypoglycemia and lactic acidosis. Regular kidney function tests must be done during treatment, and if any abnormal symptoms occur, you should consult a healthcare provider immediately. Additionally, consumption of alcohol should be avoided as it may increase the risk of lactic acidosis. This medication may increase the risk of hypoglycemia when taken together with other glucose-lowering agents, particularly insulin or sulfonylurea, so dosage adjustments may be necessary. It is advised to discontinue this medication at least 48 hours before surgery, and resumption should occur only after normal oral intake is restored and kidney function is confirmed. While taking this medication, regular blood glucose monitoring and liver, kidney function, and blood tests should be carried out to monitor for adverse reactions. Rarely, severe joint pain, skin conditions, and muscle pain may occur, so consultation with a physician is necessary if symptoms appear. In case of overdose, visit a hospital immediately for appropriate treatment; blood dialysis may be beneficial.

Serious side effects

Urticaria, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, pallor, rash, severe skin adverse reactions (Stevens-Johnson syndrome, exfoliative skin disease), acute pancreatitis, acute renal failure, dyspnea, severe allergic reactions, thrombocytopenia, severe and disabling joint pain, bullous pemphigoid, liver abnormalities (elevated liver enzymes including jaundice), sudden and severe headache, seizures, loss of consciousness

Mild side effects

• Headache
• diarrhea
• nausea
• vomiting
• abdominal pain
• upper respiratory infection
• nasopharyngitis
• constipation
• weakness
• muscle pain

This medication should be stored in a tightly sealed container to prevent air exposure, and kept at room temperature between 1 degree and 30 degrees Celsius. Storing it this way helps maintain the medication's effectiveness over time.

Appearance

Bright pink oval film-coated tablets

Package unit

30 tablets/box [(10 tablets/PTP x 3)]