Rabiduo Tablets 10/500 mg (Rabeprazole Sodium, Sodium Bicarbonate)

Adult dose

1) Gastric ulcers, duodenal ulcers: Typically, adults are prescribed 10/500 mg orally once daily. Depending on symptoms, 20/500 mg can be taken orally once daily. Generally, treatment for gastric ulcers lasts up to 8 weeks, and for duodenal ulcers, up to 6 weeks. 2) Erosive or ulcerative gastroesophageal reflux disease: Administer 10/500 mg or 20/500 mg orally once daily for 4 to 8 weeks. If proton pump inhibitors (PPIs) are given for 8 weeks and symptoms persist, an additional 8 weeks of 10/500 mg or 20/500 mg can be administered orally twice daily. However, once daily administration of 20/500 mg twice daily is limited to patients with confirmed severe mucosal injury. 3) Symptomatic relief of gastroesophageal reflux disease: Administer 10/500 mg orally once daily. If symptoms are not controlled after 4 weeks, further evaluation is necessary. Once symptoms resolve, on-demand therapy with 10/500 mg orally once daily can be used to manage any subsequently emerging symptoms. 4) Long-term maintenance therapy for gastroesophageal reflux disease: Depending on the patient, 10/500 mg or 20/500 mg can be prescribed orally once daily. 2. Patients with liver impairment: Adverse reactions of hepatic encephalopathy have been reported in patients with cirrhosis. Therefore, cautious administration is required. 3. Elderly: Caution is necessary due to often diminished liver function. 4. Children: Safety in children has not been established.

Child dose

Safety in children has not been established.

This drug should not be used in patients with an allergy or hypersensitivity to specific components. Those who are pregnant or breastfeeding should not take this medication. Patients with liver or kidney function issues, elderly patients, and those with compromised heart or lung function should exercise extra caution when using this drug. Due to the sodium bicarbonate component in this medication, patients requiring electrolyte balance or sodium intake restrictions should take it carefully. This drug may cause various side effects such as skin rash, itching, blood abnormalities, liver dysfunction, cardiovascular issues, gastrointestinal disturbances, and neurological problems, so consultation with a doctor should be sought immediately if symptoms occur. In particular, if severe allergic reactions, hepatitis, or pneumonia symptoms appear, medication should be stopped immediately, and treatment should be sought. Long-term use may lead to issues such as osteoporosis or hypomagnesemia, necessitating regular testing. This drug inhibits gastric acid secretion, thereby slightly increasing the risk of bacterial infections in the gastrointestinal tract. Caution should be taken as drowsiness may occur when driving or operating machinery. There may be interactions with other medications, so inform healthcare providers of any medications currently being taken. There are no specific antidotes for overdose; treatment should be symptomatic, and the tablets should not be chewed or crushed but swallowed whole. Keep out of reach of children and take care not to transfer to other containers.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, peeling skin, pain in mouth/eye mucosa, shortness of breath or difficulty breathing, asthma attacks, respiratory abnormalities accompanied by cough + fever, yellowing of skin or eyes (jaundice), extreme lethargy, sudden and severe headache, thunderclap headache, seizures, confusion, visual disturbances, paralysis, urine

Mild side effects

• Rash
• itching
• reduced red blood cells
• reduced white blood cells
• increased white blood cells
• increased eosinophils
• increased neutrophils
• reduced lymphocytes
• anemia
• petechiae

This drug should be stored in a sealed container to prevent exposure to air or moisture and should be kept at room temperature between 1 and 30 degrees Celsius. Storing it this way helps maintain the effectiveness of the drug and prevents deterioration.

Appearance

Bright brownish yellow oval film-coated tablet

Package unit

Bottle - 28 tablets/bottle