Januritin Combi Tablet 50/1000 Milligrams

Adult dose

This medication is usually taken twice a day with meals, and to minimize gastrointestinal adverse effects caused by metformin, the dosage should be increased gradually. 1. For patients not currently treated with metformin: - The starting dose is one tablet of this medication 50/500 mg taken twice daily. - For dose escalation, one tablet of this medication 50/1000 mg may be taken twice daily. 2. For patients currently on metformin treatment:

This medication is used for diabetes treatment and contains two ingredients, sitagliptin and metformin. While taking this medication, allergic reactions may occur, so if symptoms such as a rash, difficulty breathing, or swelling of the face or neck appear, the medication should be discontinued immediately, and a doctor consulted. Serious inflammation of the pancreas known as pancreatitis may occur, so if symptoms such as abdominal pain, nausea, or vomiting arise during treatment, inform your healthcare provider without delay. This medication is not to be administered to patients with severely impaired kidney function, acute heart failure, serious infections, or dehydration. Administration should be temporarily halted before and after examinations using iodine contrast agents, and restarted only after normal kidney function is confirmed. Pregnant women, women who may become pregnant, and nursing mothers should not take this medication. Care should be taken for the rare complication of lactic acidosis, which may present with symptoms such as muscle pain, difficulty breathing, weakness, and abdominal pain, requiring immediate medical consultation if such symptoms occur. This medication carries a risk of hypoglycemia, especially when meals are skipped or intense exercise occurs; hypoglycemia symptoms may be more pronounced when taken with other blood glucose-lowering agents. Patients with impaired liver function or excessive alcohol consumption should be cautious when taking this medication. Regular monitoring of kidney function and blood tests during treatment is recommended, as well as periodic checks of vitamin B12 levels. Interactions may occur with other medications taken alongside this drug, so all medications being taken must be disclosed to a doctor or pharmacist. In cases of surgery, this medication should be stopped 48 hours prior to surgery and can only be resumed once normal kidney function is confirmed post-surgery. Elderly patients may require dose adjustments and regular testing, given potential declines in kidney function. In case of overdose, seek immediate medical attention for appropriate treatment, as blood dialysis may be beneficial. During treatment with this medication, patients should fully understand its benefits and risks, and consistently conduct regular blood glucose checks and health assessments.

Serious side effects

• Hives
• severe swelling (angioedema)
• anaphylaxis
• chest tightness
• difficulty breathing
• skin rash
• dermatitis
• severe skin reactions
• mucosal pain in the mouth/eyes
• Stevens-Johnson syndrome

Mild side effects

• Diarrhea
• upper respiratory tract infection
• headache
• nausea
• vomiting
• abdominal pain
• constipation
• nasopharyngitis
• muscle pain
• limb pain

This medication should be stored in a tightly sealed container to prevent air exposure and kept at room temperature between 1 to 30 degrees Celsius. Proper storage will maintain the medication's efficacy over time.

Appearance

Pink oval film-coated tablet

Package unit

30 tablets/box [(10 tablets/PTP x 3)]