Janugriptin 100 mg Tablets (Sitagliptin Hydrochloride Monohydrate)

Adult dose

The usual dose of this medication is 100 mg taken once daily as monotherapy or combination therapy, and the maximum daily dose is 100 mg. It can be taken regardless of meals. For patients with renal impairment, dose adjustments are necessary based on renal function. 1. Mild renal impairment (glomerular filtration rate [eGFR] 60 or greater but less than 90) does not require dose adjustment. 2. Moderate renal impairment (glomerular filtration rate [eGFR] 45 or greater but less than 60)

This medication can cause severe allergic reactions in some patients. These reactions may occur within the first 3 months of taking the medication, and if symptoms such as hives, skin rash, or difficulty breathing occur, use should be stopped immediately and consultation with healthcare professionals is advised. Additionally, this medication may cause inflammation of the pancreas, so if symptoms like abdominal pain, vomiting, or loss of appetite appear during use, immediate medical attention is required. This medication should not be taken by patients with type 1 diabetes or those with certain allergies. Patients with decreased kidney function may require dosage adjustments, so regular kidney function testing should be performed during use. Cold-like symptoms, headache, diarrhea, and nausea may occur while taking this medication, and if symptoms are severe, consulting a physician is advised. When taken with insulin or other hypoglycemic agents, the risk of hypoglycemia may increase, so blood sugar levels should be monitored frequently, and immediate action is required if symptoms of hypoglycemia occur. If joint pain or blistering occurs, use of this medication should be stopped immediately and medical advice should be sought. Pregnant or breastfeeding women should avoid taking this medication, and safety in children under 18 years has not been adequately validated. In the case of overdose, immediate treatment is required, and some of it can be removed by hemodialysis, so medical guidance should be followed. This medication does not have significant interactions with many other drugs, but caution is necessary when used in combination with specific medications; therefore, all medications being taken must be reported to healthcare providers.

Serious side effects

Hives, severe swelling (angioedema), anaphylaxis, severe allergic reactions, rash, Stevens-Johnson syndrome, exfoliative skin disease, severe skin adverse reactions, acute pancreatitis, pancreatitis, difficulty breathing, respiratory problems, acute renal failure, elevation of liver enzymes, jaundice of skin or eyes, severe neurological symptoms (headache, seizures, confusion, visual disturbances, paralysis), severe joint pain with disability, and bullous pemphigoid.

Mild side effects

• Upper respiratory infections
• nasopharyngitis
• constipation
• vomiting
• headache
• muscle pain
• limb pain
• back pain
• itching
• thrombocytopenia

This medication should be stored in a tightly sealed container to prevent air and moisture ingress, and it is safe to store at room temperature between 1 degree and 30 degrees Celsius. Proper storage helps maintain the efficacy of the medication and prevents deterioration.

Appearance

Bright yellow-orange round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle