Januglutide 50 mg (Sitagliptin Hydrochloride Monohydrate)

Adult dose

The dosage for this medication is 100 mg once daily in either monotherapy or combination therapy, with a maximum daily dose of 100 mg. It can be taken regardless of meals. For patients with moderate renal impairment (eGFR ≥ 30 and < 45 mL/min/1.73 m2), the dosage is 50 mg once daily. For patients with severe renal impairment (eGFR ≥ 15 and < 30 mL/min/1.73 m2

This medication may cause serious allergic reactions during use; therefore, if symptoms such as skin rashes or breathing difficulties occur, it should be discontinued immediately and medical advice should be sought. During treatment with this medication, there is a risk of pancreatitis, so if symptoms such as abdominal pain or vomiting occur, medical personnel should be notified immediately. It should not be used in patients with type 1 diabetes or diabetic ketoacidosis, nor in those with a severe allergy to this medication or its components. Patients with impaired kidney function need to have their doses adjusted, hence regular kidney function tests are required. Symptoms of hypoglycemia may arise when this medication is used alone or in combination with other diabetes medications, so blood glucose levels should be monitored closely, and if necessary, consult with a physician to adjust the medication dosage. Severe joint pain or skin blistering may occur, and if these symptoms appear, the doctor should be informed immediately, and the medication should be stopped. There may be potential interactions with other medications; therefore, if any medications are currently being taken, it is imperative to inform medical professionals. Pregnant or breastfeeding women are advised not to take this medication, and safety and efficacy have not been established for children and adolescents under 18 years of age. Elderly patients may have reduced kidney function; hence, dose adjustment and kidney function tests are necessary, and in case of overdose, immediate medical treatment is required.

Serious side effects

Hives, severe swelling (edema), anaphylaxis, angioedema, chest tightness, difficulty breathing, severe allergic reactions, severe rash, blisters, skin peeling, oral/ocular mucosal pain, Stevens-Johnson syndrome, shortness of breath or difficulty breathing, asthma attacks, cough accompanied by fever and respiratory abnormalities, yellowing of the skin or eyes (jaundice), extreme lethargy, acute pancreatitis, sudden and severe headaches, seizures

Mild side effects

• Upper respiratory tract infections
• nasopharyngitis
• constipation
• vomiting
• headache
• myalgia
• limb pain
• back pain
• pruritus
• diarrhea

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture and should be kept at a temperature between 1 and 30 degrees Celsius.

Appearance

Bright yellow-orange round film-coated tablet

Package unit

30 tablets/bottle, 100 tablets/bottle