Dapamet Extended-Release Tablet 10/500 mg

Adult dose

This medication is generally administered once daily with the evening meal. The maximum dosage is 10 mg of dapagliflozin/2000 mg of extended-release metformin once daily, taken as 2 tablets of 5 mg/1000 mg. For patients with no previous experience in diabetes medication and who find it challenging to achieve adequate blood sugar control with monotherapy, an initial dosage of 5 mg/500 mg or 10 mg/500 mg tablet is recommended once daily.

This medication helps lower blood sugar levels. However, there is a risk of a rare but very serious side effect known as lactic acidosis, which may occur during treatment. Lactic acidosis is a condition in which lactic acid builds up in the body and can be life-threatening in severe cases. This medication should not be administered to patients with impaired kidney function, dehydration, severe infections, heart problems, acute myocardial infarction, and similar conditions. Additionally, it should not be used by women who are pregnant or breastfeeding. During the use of this medication, hypoglycemia may occur, especially when used with insulin or other blood sugar-lowering agents, so dosage adjustments may be necessary. This medication may cause a decrease in fluid volume and hypotension, making it essential for older adults or patients with weak kidney function to use it cautiously under medical supervision. Symptoms of genital infections or urinary tract infections may occur, so medical consultation is advised if symptoms arise. Regular blood tests are recommended to monitor potential decreases in vitamin B12 levels. During treatment, excessive alcohol consumption should be avoided, and patients should inform their doctor prior to undergoing surgery or contrast examinations, which may require pausing the medication for a period of time. Dizziness or lightheadedness may occur, requiring caution when driving or operating machinery. This medication should be kept out of the reach of children and stored in its original container for safety.

Serious side effects

Lactic acidosis, severe hypoglycemia, worsening kidney function (acute kidney injury), diabetic ketoacidosis, urosepsis and pyelonephritis, perineal necrosis, atrial fibrillation, Guillain-Barré syndrome, bacterial pneumonia, sialadenitis, acute cholecystitis, severe cutaneous adverse reactions (severe rash with fever, blisters, skin peeling, mucosal pain of mouth/eyes), severe allergic reactions (hives, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor)

Mild side effects

Vulvovaginitis, balanitis and related genital infections, urinary tract infections, fungal infections, hypoglycemia, decreased fluid volume, thirst, dizziness, constipation, dry mouth, back pain, dysuria, polyuria, nocturia, vulvar itching, genital itching, increased hematocrit, initial decrease in renal creatinine clearance, dyslipidemia, increased serum creatinine, increased blood urea, weight loss, diarrhea, nausea/vomiting, decreased vitamin B12

This medication should be stored in a tightly closed container, protected from air and moisture, and is best kept at room temperature between 1°C and 30°C. Proper storage helps maintain the efficacy of the medication and prevents degradation.

Appearance

Pink, oval-shaped, double-convex film-coated tablet

Package unit

Bottle - 30 tablets/bottle, Box - 30 tablets/box [6 tablets (Alu-Alu) x 5]