Excigluem Sustained-release Tablet 5/500 mg

Adult dose

This medication is typically taken once daily with the evening meal. The maximum dosage is 10 mg of dapagliflozin and 2000 mg of sustained-release metformin once daily, which can be administered as 2 tablets of 5 mg/1000 mg. When used as initial therapy, the recommended starting dosage is 1 tablet of 5 mg/500 mg or 10 mg/500 mg once daily. To reduce gastrointestinal side effects associated with metformin, the dosage should be adjusted gradually.

This medication helps control blood sugar levels. However, it may rarely cause a serious condition known as lactic acidosis, so caution is warranted. When using this medication, there is a risk of hypoglycemia when taken with insulin or sulfonylureas, so care should be taken. This medication should not be used in patients with severely reduced kidney function, dehydration, serious infections, cardiovascular issues, or acute myocardial infarction. Additionally, pregnant or nursing women, patients with lactose intolerance, and those undergoing dialysis should not take this medication. Before taking the medication, it is essential to check fluid volume and kidney function, especially in elderly patients or those with compromised kidney function. This medication may increase the risk of genital infections or urinary tract infections; hence, if symptoms of infection appear, prompt consultation with a physician is necessary. Hypoglycemic symptoms may occur, so dosage adjustment may be needed when used in combination with insulin or other hypoglycemic agents. While taking this medication, there may be rare side effects such as dizziness, dry mouth, constipation, and back pain; if any unusual symptoms occur, they should be reported. This medication should not be administered to patients with impaired liver function, and alcohol consumption should be avoided due to an increased risk of lactic acidosis. Before surgery or radiologic examinations, this medication should be stopped for a certain period, and only resumed once normal kidney function is confirmed. Vitamin B12 deficiency may occur, so regular monitoring of serum vitamin B12 levels is advisable. In cases of overdose, immediate medical attention should be sought, and this medication should not be used by children or pregnant women. During treatment, caution should be exercised about dizziness when driving or operating machinery, and it should be stored in its original container out of reach of children.

Serious side effects

Hives, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, pain in oral/ocular mucosa, shortness of breath or difficulty breathing, asthma attacks, cough with fever, changes in skin or eye color, extreme fatigue, sudden and severe headache, lightning headache, seizures, confusion, visual disturbances, paralysis, significantly reduced urine output

Mild side effects

• Hypoglycemia
• dizziness
• constipation
• dry mouth
• back pain
• dysuria
• polyuria
• nocturia
• itching of the genital area
• itching of the external genitalia

This medication should be stored in a tightly closed container to prevent exposure to air or moisture and kept at room temperature between 1°C and 30°C.

Appearance

Orange, double convex, rectangular sustained-release film-coated tablet

Package unit

10 tablets/box [10 tablets/PTP x 1], 30 tablets/bottle, 30 tablets/box [10 tablets/PTP x 3]