AviSmet Tablet 50/500 mg

Adult dose

In the treatment of patients with type 2 diabetes, the dose of Vildagliptin should not exceed 100 mg and Metformin should not exceed 2000 mg, based on efficacy and tolerability considerations. A dosage of more than 100 mg of Vildagliptin per day is not recommended. Administering it with food or immediately after meals may reduce gastrointestinal adverse effects associated with Metformin. 1. For patients with no previous experience of diabetes medication treatment, this medication should be initiated at a dose of 50/500 mg once daily, taking one tablet per dose, and may be gradually increased to 50/1000 mg twice daily, taking one tablet per dose. 2. For patients transitioning from the combination therapy of Vildagliptin and Metformin: Patients transitioning from the combination therapy of Vildagliptin and Metformin can start at their previously prescribed doses. Studies evaluating the safety and efficacy of switching from other oral hypoglycemic agents to this medication have not been conducted. Any changes in the treatment regimen for type 2 diabetes may affect blood sugar control, so caution should be exercised, and adequate monitoring should be implemented. If a dose is missed, take it with the next meal except when it is close to the next scheduled dose, and do not take two doses at once to make up for a missed one. Patients with liver dysfunction: This medication is not recommended for patients with evidence of clinical or laboratory abnormalities related to liver dysfunction, including those with ALT or AST levels exceeding 2.5 times the normal upper limit before administration.

This medication may cause severe lactic acidosis or hypoglycemia; therefore, it should not be administered to patients with moderately severe or worse renal impairment, those with heart failure, or patients with acute heart disease. Before undergoing tests using radiographic iodine contrast agents, this medication should be discontinued at least 48 hours prior to the examination and should only be resumed after confirming normal kidney function post-examination. Patients with hypersensitivity to this medication, as well as those with type 1 diabetes, diabetic ketoacidosis, severe infections, or significant liver or lung dysfunction, should not use this medication. It is recommended that this medication not be used in pregnant or nursing women. When there are irregular meals, intense exercise, or drug interactions, caution should be taken to avoid the risks of lactic acidosis and hypoglycemia. During the use of this medication, side effects such as headaches, dizziness, nausea, and hypoglycemia may occur; if symptoms are severe, consult a doctor immediately. Liver function abnormalities may occur, so it is important to conduct liver function tests before taking this medication and regularly monitor liver function during use. If renal function is impaired, the risk of lactic acidosis increases due to the accumulation of this medication, so regular kidney function tests should be performed, and the medication should be discontinued if kidney function worsens. This medication does not replace insulin treatment and should not be used for patients with type 1 diabetes. In case of overdose, seek medical attention immediately, and blood dialysis may be beneficial. Alcohol consumption may increase the risk of lactic acidosis, so it is advisable to avoid drinking while on this medication. Elderly patients often have decreased renal function, so kidney function should be tested frequently when taking this medication, and dosage adjustments may be necessary. The safety and efficacy of this medication have not been established in children and adolescents, so its use is not recommended. If bullous skin lesions or severe joint pain occur, consult a doctor immediately, and consideration should be given to discontinuing the medication should these symptoms arise. Regular monitoring of blood sugar levels is necessary during treatment, and appropriate actions should be taken if blood sugar levels fall too low.

Serious side effects

• Hives
• angioedema
• blisters
• exfoliative skin lesions
• hepatitis
• lactic acidosis
• hypoglycemia
• severe edema
• severe allergic reactions
• liver abnormalities (jaundice)

Mild side effects

• Tremors
• headaches
• dizziness
• fatigue
• nausea
• gastroesophageal reflux
• diarrhea
• bloating
• chills
• decreased blood sugar

This medication is sensitive to air and moisture, so it should be stored in a tightly sealed container. It is best to maintain a storage temperature between 1 and 30 degrees Celsius at room temperature. Proper storage maintains the effectiveness of the medication and prevents degradation.

Appearance

Bright yellow oval film-coated tablet

Package unit

30 tablets/PTP [10 tablets/PTP packaging x 3]