Tranexamic Acid 500 mg Tablet

Adult dose

As tranexamic acid, the usual adult dosage is 750 to 2000 mg per day, divided into 3 to 4 oral doses. The dosage may be adjusted according to age and symptoms.

This medication should not be used in patients receiving thrombin or those with severe renal failure. Additionally, it should not be administered to patients with allergic reactions to this medication or its components, or those with active thromboembolic disease. Caution is advised when used in patients with thrombosis or those at risk of thromboembolism, as well as in patients who have been bedridden for long periods post-surgery or receiving pressure hemostasis, as they are at an increased risk of thrombosis. Care must be taken in renal failure patients, as drug concentrations in the blood may increase. Rarely, hypersensitivity reactions such as shock, itching, rash, and flushing may occur; if such symptoms appear, administration should be stopped immediately, and appropriate treatment should be sought. Temporary alteration in color perception may occur, and if this symptom arises, the medication should be discontinued. Massive hematuria may occur in the upper urinary tract, particularly in hemophilia patients who may be at risk of ureteral obstruction. Gastrointestinal symptoms may include loss of appetite, nausea, vomiting, diarrhea, and abdominal discomfort. Additionally, drowsiness, headache, and arterial and venous thrombosis have rarely been reported; if these symptoms occur, consultation with a physician is recommended. Patients using this medication for a prolonged period are advised to have regular eye examinations and liver function tests. Patients with irregular menstrual bleeding should refrain from using this medication until the cause of the bleeding is identified, and if menstrual bleeding does not decrease, alternative treatments should be considered. This medication may increase the formation of blood clots when used with thrombin or hemostatic drugs, thus co-administration should be avoided or done with caution. Women using hormonal contraceptives may be at increased risk for thromboembolism and are advised to consider non-hormonal contraceptive methods. During pregnancy, as it can cross the placenta, it should be used with caution; while small amounts of the drug can be excreted in breast milk during lactation, it is expected to have little impact on infants. Safety in pediatric patients under 15 years has not been fully established, so caution is necessary. Elderly patients may have decreased physical function and should use this medication with dosage adjustments and care. In cases of overdose, symptoms such as nausea, vomiting, and orthostatic hypotension may occur, requiring treatment including inducing vomiting, gastric lavage, and activated charcoal administration, with adequate fluid intake maintained. Anticoagulant treatment should also be considered if there is a risk of thrombus formation. Finally, prolonged high-dose administration in animal studies has reported retinal changes, thus caution is warranted for long-term use.

Serious side effects

Shock, massive hematuria in the upper urinary tract, ureteral obstruction, arterial and venous thrombosis, thromboembolism

Mild side effects

• Itching
• rash
• flushing
• temporary alteration in color perception
• loss of appetite
• nausea
• vomiting
• diarrhea
• abdominal discomfort
• drowsiness

This medication may be sensitive to air or moisture; therefore, it should be stored in a tightly sealed container. It is advisable to maintain the storage temperature between 1 degree and 30 degrees Celsius at room temperature. Storing it this way helps retain the drug's efficacy and safety over time.

Appearance

White to off-white oval tablet

Package unit

100 tablets/PTP (10 tablets/PTP*10)