HILUSMET Tablets

Adult dose

The dosage of this medication should be individualized based on efficacy and tolerability without exceeding 100 mg of vildagliptin and 2000 mg of metformin. Doses greater than 100 mg of vildagliptin daily are not recommended. Generally, administration with food or immediately after meals can reduce gastrointestinal adverse reactions associated with metformin. 1. For patients who have no previous experience with diabetes medication and where monotherapy is insufficient for adequate blood sugar control: The initial dose of this medication should be 50/500 mg once daily, which can gradually be increased to 50/1000 mg, up to twice daily, one tablet at a time. 2. For patients switching from a combination therapy of vildagliptin and metformin: Patients switching from the combination therapy of vildagliptin and metformin can start at the existing doses of vildagliptin and metformin. Studies evaluating the safety and efficacy of switching from other oral hypoglycemic agents to this medication have not been conducted. Any changes in the treatment regimen for type 2 diabetes can lead to changes in blood sugar control, so appropriate monitoring is necessary. If a dose is missed, it should be taken with the next meal unless it's the time for the next scheduled dose; do not take a double dose to make up for a missed one. For patients with liver impairment, this medication is not recommended for patients with clinical or laboratory evidence of liver disease, including those with ALT or AST levels exceeding 2.5 times the upper limit of normal.

This medication should be used with great caution as it can cause severe lactic acidosis or hypoglycemia. It should not be used in patients with moderate to severe renal impairment, heart failure, acute heart disease, or sepsis. Prior to examinations using radiological iodine contrast agents, this medication should be discontinued at least 48 hours in advance, and it should only be resumed after confirming normal kidney function. It should not be administered to patients with hypersensitivity to this medication or those with type 1 diabetes or diabetic ketoacidosis. If a patient has severe infections, serious trauma, during and after surgery, malnutrition, liver dysfunction, pulmonary dysfunction, excessive alcohol consumption, etc., the use of this medication should be temporarily halted and resumed only once the condition improves. It is advisable to avoid using this medication in pregnant or nursing women. This medication should be used carefully in cases of irregular meals, intense exercise, or interactions with other medications, and patients with allergies to certain dyes should be cautious. During treatment, liver and kidney functions must be regularly checked to ensure there are no abnormalities; if hepatic impairment is detected, discontinue use. Due to the risk of lactic acidosis, if dehydration, hypoxemia, severe diarrhea, or vomiting occurs, the use of this medication should be stopped immediately and a physician should be consulted. Alcohol may increase the risk of side effects from this medication, thus it should be avoided while taking it. Hypoglycemic symptoms may occur, so blood sugar levels should be closely monitored, especially when taken with other hypoglycemic agents. This medication is not recommended for children under 18 years old, and dosage adjustment may be necessary for elderly patients depending on renal function. In case of overdose, blood dialysis may be required, and immediate medical attention should be sought. If any abnormal skin symptoms such as blisters or ulcers develop while taking this medication, consult a doctor immediately. Caution should be taken as dizziness or drowsiness may occur when driving or operating machinery.

Serious side effects

• Hives
• angioedema
• hepatitis
• blisters and exfoliative skin lesions
• acute pancreatitis
• lactic acidosis
• severe allergic reactions
• severe skin adverse reactions
• liver abnormalities (jaundice)
• severe edema or urinary issues

Mild side effects

• Tremor
• headache
• dizziness
• fatigue
• nausea
• gastroesophageal reflux
• diarrhea
• bloating
• weakness
• sweating

This medication is sensitive to air and humidity, thus it should be stored in a tightly sealed container. The storage temperature should be maintained at room temperature between 1 degree and 30 degrees. This helps preserve the effectiveness of the medication for a longer period.

Appearance

Bright yellow oval film-coated tablet

Package unit

30 tablets/box [(10 tablets/PTP X3)]