Ezetimibe/Phenofibrate Tablets

Adult dose

The usual dosage for adults is 1 tablet taken immediately after a meal once daily. Since the phenofibrate component may be less absorbed on an empty stomach, it should be taken immediately after meals.

This medication should not be administered to certain patients. For example, individuals with allergies to this medication or its ingredients should not take it. Patients with severe liver disease or persistently elevated liver enzyme levels without explanation should not receive this medication along with other specific lipid-lowering agents. Women who are pregnant or may become pregnant, as well as breastfeeding mothers, should not take this medication. Additionally, patients with impaired liver function, severe kidney impairment, or gallbladder disease should avoid this drug. Patients who have experienced phototoxic reactions during certain drug treatments, children, and patients with biliary cirrhosis or pancreatitis should also refrain from using this medication. Those with genetic issues such as lactose intolerance should not take this drug. Patients with slightly reduced kidney function, liver dysfunction, bleeding disorders, elderly patients, and others must use this medication cautiously. In particular, for cases of slightly impaired kidney function, the dosage may need to be reduced or the dosing interval extended. This medication may cause side effects such as headache, abdominal pain, diarrhea, myalgia, and fatigue. Furthermore, liver enzyme levels may increase, necessitating regular liver function tests. If muscle pain or weakness is felt, the patient should immediately inform their physician; in severe cases, the medication should be discontinued. This medication can interact with other lipid-lowering agents, anticoagulants, immunosuppressants, etc., so patients taking other medications must consult their doctor. Pregnant or breastfeeding women should avoid using this medication due to potential effects on the fetus during pregnancy, for which caution is advised. Children should not take this medication, and elderly patients should periodically check liver and kidney function while using it. In cases of overdose, there is no specific antidote, so appropriate treatment according to the symptoms is necessary, and it is vital to keep this medication out of the reach of children. This medication should be used in conjunction with dietary changes and lifestyle improvement, and regular blood tests and liver function tests should be conducted during treatment.

Serious side effects

Urticaria, severe swelling (edema), anaphylaxis, allergic reactions including rash and angioedema, severe allergic reaction, rash and angioedema, erythema multiforme, skin peeling, pain in mucous membranes of the mouth/eyes, severe skin reactions, significant edema, systemic edema accompanied by elevated blood pressure, difficulty breathing or shortness of breath, respiratory issues, yellowing of the skin or eyes (jaundice), liver abnormalities, sudden and severe headaches.

Mild side effects

• Fatigue
• abdominal pain
• diarrhea
• viral infections
• pharyngitis
• sinusitis
• arthralgia
• low back pain
• cough
• chest pain

This medication must be stored in a tightly sealed container to avoid exposure to air and moisture. Additionally, it should not be kept in excessively hot or cold places and is best stored at room temperature between 1°C and 30°C.

Appearance

White circular film-coated tablet

Package unit

30 tablets/PTP[(10 tablets/PTP×3)], 30 tablets/bottle, 100 tablets/bottle