Damec Extended Release Tablets 10/1000 Milligrams

Adult dose

The dosage of this medication should be individualized based on the patient's current treatment regimen, efficacy, and tolerability, without exceeding the maximum recommended doses of dapagliflozin 10 mg and sustained-release metformin 2000 mg. This medication is generally administered once daily with the evening meal. The maximum dosage is once daily dapagliflozin 10 mg/sustained-release metformin 2000 mg, taken as 2 tablets of 5 mg/1000 mg. In cases where previous diabetes medication treatment experience is absent and adequate glycemic control is difficult with monotherapy: When initiated as initial therapy in a patient without previous diabetes treatment experience, the recommended starting dose is 1 tablet once daily of either 5 mg/500 mg or 10 mg/500 mg. Gradually adjust the dosage to reduce gastrointestinal side effects of metformin. For patients on metformin treatment, the recommended dose of dapagliflozin is 10 mg once daily, and this dosage should provide a dose equivalent to the amount of metformin being taken or a therapeutically close appropriate dose. When converting from immediate-release to sustained-release metformin, blood sugar control should be closely monitored, and dosage adjustments should be made as necessary. For patients switching to this medication from combined therapy with dapagliflozin and metformin, the starting dosage can be based on the existing dosing amounts for both medications. When converting from immediate-release to sustained-release metformin, blood sugar control should be closely monitored, and dosage adjustments should be made as necessary. When used in combination with insulin or insulin secretagogues like sulfonylureas, lower doses of insulin or insulin secretagogues may be considered to mitigate the risk of hypoglycemia. The safety and efficacy of this medication in patients switched from other hypoglycemic agents have not been specifically evaluated. Changes in glycemic control can occur, necessitating careful monitoring of any modifications within the treatment for type 2 diabetes. This medication should be swallowed whole and should not be crushed, cut, or chewed. Occasionally, the inactive ingredients of this medication may be excreted in the stool in the form of soft hydrates resembling tablets. Renal impairment No dose adjustments are necessary for patients with mild renal impairment. For patients with an estimated GFR (eGFR) between 45 mL/min/1.73 m² and below 60 mL/min/1.73 m² without other symptoms that could increase the risk of lactic acidosis, the starting dose containing the active ingredient metformin hydrochloride is 500 mg once daily, with a maximum daily dose of 1000 mg. The use of this medication is not recommended in patients with an eGFR below 45 mL/min/1.73 m². If the estimated GFR falls below 45 mL/min/1.73 m², the use of this medication must be immediately discontinued. Renal function should be assessed every 3-6 months. Elderly patients Metformin is excreted via the kidneys, and the elderly are more prone to renal function decline, so this medication should be used with caution as age increases (refer to the precautions regarding the administration to elderly patients).

This medication can very rarely cause serious lactic acidosis, so renal function and general health status must be confirmed before use. When used with other diabetes medications, there may be a risk of hypoglycemia, necessitating careful monitoring of blood sugar levels. Patients with moderate to severe renal impairment, severe infections, dehydration, or acute cardiovascular diseases should not use this medication. Before surgery or radiographic iodine contrast examinations, this medication should be discontinued for a period, and restarts should only occur after confirming normal renal function. Women who are pregnant or breastfeeding should not take this medication, and caution is warranted for use in children and the elderly. During treatment with this medication, regular checks for symptoms of hypoglycemia, dehydration, infection, and so forth are necessary, and immediate medical consultation is warranted in case of any abnormal symptoms. Long-term use may reduce vitamin B12 levels; therefore, regular blood tests are recommended. Alcohol intake may increase the risk of side effects; therefore, excessive drinking should be avoided while on this medication. This medication may increase the risk of genital and urinary infections, so personal hygiene should be monitored, and immediate treatment sought if infection symptoms appear. Patients with decreased fluid volume or risk of hypotension should frequently monitor blood pressure and fluid status, and dose adjustments may be necessary if needed. This medication can interact with other drugs; therefore, inform healthcare professionals of any other medications being taken. In the case of overdose, immediately visit a healthcare facility for appropriate treatment; this medication may be removed via dialysis. Caution is necessary when driving or operating machinery, as dizziness and other symptoms may occur.

Serious side effects

Hives, severe swelling, chest tightness, difficulty breathing, cold sweat, paleness, severe rash with high fever, blisters, skin peeling, mucosal pain in the mouth/eyes, shortness of breath or difficulty in breathing, asthma attacks, respiratory issues accompanied by cough and fever, yellowing of the skin or eyes, profound fatigue, sudden severe headache, thunderclap headache, seizures, altered consciousness, visual disturbances, paralysis, markedly reduced urine output

Mild side effects

• Hypoglycemia
• dry mouth
• dizziness
• constipation
• xerostomia
• low back pain
• dysuria
• polyuria
• nocturia
• vulvar itching

This medication should be stored in a tightly sealed container to prevent exposure to air or moisture. The recommended storage temperature is between 1 and 30 degrees Celsius at room temperature, which helps maintain the medication's effectiveness for a longer duration.

Appearance

Yellow, dual convex, egg-shaped film-coated tablet

Package unit

30 tablets/bottle