Esomeprazole Magnesium Trihydrate 20/800 mg Tablets

Adult dose

This medicine should be taken on an empty stomach at least 1 hour before meals. When taking this medicine, it should be swallowed whole with at least half a cup of water. Do not take with any beverages other than water. This medicine should not be chewed or crushed. For treatment of erosive reflux esophagitis: Administer 40/800 mg once daily for 4 weeks. In patients whose esophagitis is not resolved or whose symptoms persist, it may be taken for another 4 weeks.

It is essential not to use this medicine in certain patients. Patients who are allergic to this medicine or its ingredients, or who have had hypersensitivity reactions in the past, should not use this medicine. Furthermore, it is contraindicated for pregnant women, women who are breastfeeding, patients taking the antiviral drugs Atazanavir or Nelfinavir, and those with a history of myocardial infarction. Use with caution in patients with liver or kidney dysfunction, elderly patients, patients with impaired heart or lung function, patients with severe gastrointestinal ulcers, patients with electrolyte imbalances, and patients who need to restrict sodium intake. Particularly, the Sodium Bicarbonate component in this medicine may cause alkalosis or edema due to sodium accumulation, so the patient's condition should be closely monitored. This medicine can cause various side effects. Blood-related issues such as leukopenia or thrombocytopenia may occur, along with hypersensitivity reactions such as fever, angioedema, or anaphylactic shock. Electrolyte imbalances including hyponatremia and hypomagnesemia have been reported, while psychological symptoms may include insomnia, anxiety, depression, and hallucinations. Neurological symptoms such as headaches, dizziness, and drowsiness are common, whereas gastrointestinal symptoms such as abdominal pain, diarrhea, constipation, nausea, and vomiting occur relatively frequently. Rarely, liver dysfunction, skin rash, hair loss, or severe skin reactions (such as Stevens-Johnson syndrome) have also been reported. Since this medicine inhibits gastric acid secretion, bacterial overgrowth in the gastrointestinal tract may increase, raising the risk of specific bacterial infections. Long-term use may increase the risk of osteoporosis-related fractures, so patients at high risk of fractures require regular examinations. This medicine can interact with other medications, so when taken with anticoagulants, antiviral drugs, anticonvulsants, antidepressants, etc., it is crucial to closely monitor drug concentrations and effects under a doctor's guidance. The safety of this medicine during pregnancy has not been entirely confirmed, so caution is advised when using it. It is recommended not to take this medicine while breastfeeding. In case of overdose, there are no specific antidotes, so it is crucial to receive symptomatic treatment, and keep it out of reach of children. During treatment with this medicine, if symptoms change or adverse reactions occur, it is necessary to consult a doctor immediately.

Serious side effects

Hives, angioedema, anaphylaxis reaction/shock, severe allergic reaction, severe skin adverse reactions, Stevens-Johnson syndrome, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, eosinophilia and systemic symptoms drug reaction, liver failure, jaundice, liver dysfunction, severe neurological symptoms, seizures, altered consciousness, visual disturbances, paralysis, severe edema, urination abnormalities

Mild side effects

• Headache
• dizziness
• paresthesia
• drowsiness
• blurred vision
• bronchospasm
• abdominal pain
• constipation
• diarrhea
• abdominal distension

This medicine must be stored in a tightly sealed container to protect it from air and moisture. It is best to keep it at room temperature between 1 and 30 degrees Celsius to maintain the medicine's efficacy.

Appearance

Light pink, rectangular film-coated tablets

Package unit

28 tablets/box [(7 tablets/PTP × 4)]