Medication info
Donepezil 23 mg (Donepezil Hydrochloride Hydrate)

Donepezil 23 mg (Donepezil Hydrochloride Hydrate)

Prescription medicationTablet경구
Ingredient · strength
Donepezil Hydrochloride Hydrate›24mg / 1 tablet
Manufacturer / importer
에스에스팜(주)
Appearance
Red, double-sided, convex, round film-coated tablets
Packaging
30 tablets/bottle
Approval status
Active

MFDS item code 202103201 · Approved 2021.04.20 · Insurance code 663300980

Summary

Main use
Treatment of moderate to severe Alzheimer's type dementia symptoms
Who takes it
Adults
Adult dose
This medication is taken once daily just before bedtime and can be administered regardless of meals. The initial recommended dose of donepezil hydrochloride is 5 mg taken once daily. Normalcy is reached after 15 days, and for 4 to 6 weeks, 5 mg is administered. After evaluating clinical responses, it may be increased to 10 mg, with caution for gastrointestinal adverse reactions at a daily dosage of 10 mg. It should be taken for at least 3 months at a dose of 10 mg once daily.

Ingredients

Manufacturer
에스에스팜(주)

Efficacy & effects

Treatment of moderate to severe Alzheimer's type dementia symptoms

  • Alzheimer's type dementia symptoms
View approved original text

This medication is used to treat moderate to severe symptoms of Alzheimer's type dementia. It can improve memory decline, cognitive function impairment, and damage to daily living abilities. It helps enhance the quality of life for patients and has an effect of slowing the progression of dementia symptoms.

How to take

Adult dose

This medication is taken once daily just before bedtime and can be administered regardless of meals. The initial recommended dose of donepezil hydrochloride is 5 mg taken once daily. Normalcy is reached after 15 days, and for 4 to 6 weeks, 5 mg is administered. After evaluating clinical responses, it may be increased to 10 mg, with caution for gastrointestinal adverse reactions at a daily dosage of 10 mg. It should be taken for at least 3 months at a dose of 10 mg once daily.

Precautions

This medication should not be used by individuals who have allergies to specific ingredients, are pregnant, or are nursing. Patients with heart disease or heart rhythm problems should exercise caution when using this drug and regularly check their heart condition. Patients with a history of peptic ulcers or gastrointestinal bleeding should carefully observe symptoms as this medication may promote gastric acid secretion. Patients with asthma or obstructive pulmonary disease should use it cautiously as bronchial constriction may worsen. Patients with extrapyramidal disorders such as Parkinson's disease should be careful as this medication may aggravate symptoms. It contains specific dyes, so patients allergic to these components should exercise caution. Serious side effects such as abnormal heart symptoms, gastrointestinal bleeding, liver dysfunction, seizures, muscle disorders, and difficulty breathing may occur during the use of this medication, so if such symptoms appear, they should consult a doctor immediately. Some patients may experience relatively common side effects such as nausea, vomiting, diarrhea, appetite loss, dizziness, insomnia, drowsiness, itching, rash, muscle pain, muscle cramps, incontinence, frequent urination, constipation, abdominal pain, thrombocytopenia, purpura, dizziness, anxiety, hallucinations, aggressive behavior, tremors, gait disorders, involuntary movements, confusion, delusions, rambling, hyperactivity, nightmares, nervousness, depression, stupor, insomnia, and increased libido. This medication is not approved for other forms of memory disorders other than dementia and should be used under the diagnosis and supervision of a specialist. This drug may slow down heart rate or cause arrhythmias, so patients with cardiac conditions may require periodic electrocardiograms. It may affect the digestive system, and patients with a history of peptic ulcers or those taking non-steroidal anti-inflammatory drugs should carefully observe symptoms. Neurological symptoms such as seizures or extrapyramidal symptoms may occur, so patients with such conditions should take extra precautions. It is advisable for pregnant or nursing women not to use this medication, and if necessary, should consult a professional before use. This medication has not been established as safe for children and should not be used in pediatric patients. This medication may interact with several drugs, so patients should inform their medical personnel if they are taking other medications and must be managed carefully. In case of overdose, serious symptoms such as nausea, vomiting, bradycardia, and respiratory depression may occur, requiring immediate emergency treatment, and atropine can be used as an antidote. When storing this medication, it should be kept in a tightly sealed container to prevent air or moisture from entering, and it is best to store at room temperature between 1 and 30 degrees Celsius. Therefore, avoid extremely hot or cold places and store it at an appropriate temperature to maintain the drug's effectiveness.

Side effects and when to seek care immediately

Serious side effects

Hives, severe swelling, chest tightness, difficulty breathing, cold sweat, pallor, severe rash with high fever, blisters, pain in mucous membranes of the mouth/eyes, shortness of breath or difficulty breathing, asthma attacks, cough with fever accompanied by respiratory difficulties, yellowing of skin or eyes (jaundice), extreme lethargy, sudden and very severe headaches, lightning headaches, seizures, disorientation, vision abnormalities, paralysis, significantly reduced urine output

Mild side effects

  • Nausea
  • vomiting
  • diarrhea
  • appetite loss
  • headache
  • fatigue
  • lethargy
  • dizziness
  • insomnia
  • drowsiness
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  • itching
  • rash
  • muscle pain
  • muscle cramps
  • incontinence
  • frequent urination
  • constipation
  • abdominal pain
  • thrombocytopenia
  • purpura
  • dizziness
  • anxiety
  • hallucinations
  • aggressive behavior
  • tremors
  • gait disorders
  • involuntary movements
  • drowsiness
  • insomnia
  • confusion
  • delusions
  • rambling
  • hyperactivity
  • nightmares
  • nervousness
  • depression
  • stupor
  • insomnia
  • increased libido

Not everyone experiences these, and they can vary from person to person.

Storage

This medication should be kept in a tightly sealed container to prevent air or moisture from entering, and it is advisable to store it at room temperature between 1 and 30 degrees Celsius. Therefore, avoid excessively hot or cold places, and store it at an appropriate temperature to maintain the drug's effectiveness.

Appearance and packaging

Appearance

Red, double-sided, convex, round film-coated tablets

Package unit

30 tablets/bottle

Same-ingredient medicines

Even with the same ingredient, strength, dosage form and how it is taken can differ.

Even with the same ingredient, the dose and directions can differ by strength and dosage form. Talk to a doctor or pharmacist before switching from a medication you are already taking.

Questions about this medicine

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For anything that needs medical judgment, consult a doctor or pharmacist.

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This drug information is based on data provided by the Korea Ministry of Food and Drug Safety.
Consult a doctor or pharmacist for accurate dosage, administration, and usage instructions.