Janusitin Tablets 25 mg (Sitagliptin Hydrochloride Hydrate)

Adult dosage

The recommended dosage of this drug is 100 mg once daily for both monotherapy and combination therapy, with a maximum daily dosage of 100 mg. This drug can be taken regardless of meals. Dosage adjustment for patients with renal impairment: - For mild and moderate renal impairment (glomerular filtration rate 45 or more but less than 90), no dosage adjustment is necessary. - For patients with moderate renal impairment with a glomerular filtration rate of 30 or more but less than 45, the dose is 50 mg once daily.

This drug may cause severe allergic reactions after administration, so if symptoms like skin rash or difficulty in breathing occur, stop taking it immediately and consult a healthcare professional. Furthermore, serious inflammation of the pancreas known as pancreatitis may occur, so if symptoms such as abdominal pain or vomiting appear, you should go to the hospital immediately. This drug should not be used in patients with type 1 diabetes or diabetic ketoacidosis, and should be avoided in cases of hypersensitivity to this drug or its components. Patients with impaired renal function should have their dosage adjusted; therefore, they should take it according to their doctor's instructions. When used in combination with other hypoglycemic agents like insulin or sulfonylureas, the risk of hypoglycemia may increase, so blood sugar levels should be checked regularly. If severe joint pain or blisters appear during treatment, inform your doctor immediately and discontinue the medication. Women who are pregnant or breastfeeding should preferably avoid taking this drug, and its safety and efficacy have not been established for children under 18 years of age. In elderly patients, renal function may decline, so it is important to undergo renal function tests before administration and to take it carefully. In case of overdose, immediate medical attention should be sought and appropriate treatment should be provided, as this drug can be partially removed by hemodialysis. It is important to consult your doctor or pharmacist when taking this drug with other medications due to the possibility of interactions.

Serious side effects

Urticaria, angioedema, anaphylaxis, severe hypersensitivity reactions, exfoliative skin disorders including Stevens-Johnson syndrome, severe rash with high fever, blisters, skin peeling, pain in oral/ocular mucosa, acute pancreatitis, acute renal failure, severe edema, cardiac arrest, pneumonia, severe allergic reactions, severe skin adverse reactions, worsening renal function, severe and disabling arthralgia, bullous pemphigoid, rhabdomyolysis

Mild side effects

• Hypoglycemia
• upper respiratory infection
• nasopharyngitis
• headache
• diarrhea
• nausea
• abdominal pain
• constipation
• vomiting
• peripheral edema

This drug should be stored in a tightly closed container that is airtight, and it is important to keep it at room temperature between 1 degree and 30 degrees Celsius. Proper storage helps maintain the efficacy of the drug and prevent deterioration.

Appearance

Bright yellow-orange round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle - 30 tablets/bottle, 30 tablets/bottle, 100 tablets/bottle - 100 tablets/bottle