Janusitin Tablet 50 mg (Sitagliptin Hydrochloride Hydrate)

Adult dosage

This medication is administered as 100 mg once daily, whether as monotherapy or in combination therapy, with a maximum daily dosage of 100 mg. It can be taken regardless of meals. For patients with kidney impairment, dosage adjustments are necessary for those with mild to moderate kidney impairment (eGFR 45 to < 90), no dosage adjustment is needed. For patients with moderate kidney impairment (eGFR 30 to < 45), the dose is administered as 50 mg once daily. For patients with severe kidney impairment (

This medication can cause severe allergic reactions, therefore, if symptoms such as skin rash, difficulty breathing, or swelling of the face or neck occur after taking the drug, stop taking it immediately and consult a doctor. Severe inflammatory pancreatitis may occur during the use of this medication; if symptoms such as abdominal pain, nausea, or vomiting appear, contact healthcare professionals immediately. Patients with type 1 diabetes or diabetic ketoacidosis should not take this medication, and it should also not be taken by those who are allergic to this medication or its components. Patients with impaired kidney function need to adjust the dosage of this medication, and those with severely impaired kidney function need to exercise additional caution. Light adverse reactions such as cold symptoms, headache, rhinitis may occur during the course of this medication, and hypoglycemia may also occur, so it is essential to manage blood sugar carefully. This medication increases the risk of hypoglycemia when taken with other hypoglycemic agents, particularly insulin or sulfonylureas, so dosage adjustments may be necessary in these cases. If symptoms such as severe joint pain or blisters on the skin occur during the use of this medication, consult a physician immediately and stop taking the drug. Use of this medication is not recommended for pregnant or breastfeeding women, and safety in children under 18 years of age has not been established. Elderly patients may experience decreased kidney function more easily, so it is advisable to undergo kidney function tests before starting this medication and to monitor kidney function regularly. In the case of overdose, emergency treatment such as removing the drug from the gastrointestinal tract may be necessary, and this medication can be partially removed through dialysis if needed.

Serious side effects

• Hives, angioedema, anaphylaxis, severe allergic reactions
• Acute pancreatitis, fatal/non-fatal hemorrhagic or necrotizing pancreatitis
• Acute renal failure (sometimes requiring dialysis)
• Severe joint pain accompanied by disability
• Bullous pemphigoid
• Elevated liver enzymes, liver abnormalities (including jaundice)
• Severe hypoglycemia
• Cardiac arrest
• Pneumonia
• Diabetes complications

Mild side effects

• Upper respiratory infection
• nasopharyngitis
• headache
• nausea
• diarrhea
• constipation
• myalgia
• limb pain
• back pain
• pruritus

This medication should be stored in a sealed container to prevent air ingress and it is safe to store at room temperature between 1 degree and 30 degrees Celsius. Storing it this way helps maintain the effectiveness of the medication over a longer period.

Appearance

Bright yellow-orange round film-coated tablets

Package unit

30 tablets/bottle, 100 tablets/bottle - 30 tablets/bottle, 30 tablets/bottle, 100 tablets/bottle - 100 tablets/bottle