Danubia Tablet 25 mg (Sitagliptin Hydrochloride Hydrate)

Adult dosage

The recommended dosage for this medication is 100 mg once daily for monotherapy or combination therapy, with a maximum daily dose of 100 mg. Patients with renal impairment need dosage adjustments based on renal function. - Mild and moderate renal impairment do not require dosage adjustments. - Patients with moderate renal impairment (glomerular filtration rate 30-45 mL/min/1.73 m2) should take 50 mg once daily. - Patients with a glomerular filtration rate of 15-30 mL/min/...

This medication may cause severe allergic reactions after administration; therefore, if symptoms such as rash or difficulty breathing occur, discontinue use immediately and seek medical attention. There is a risk of pancreatitis (inflammation of the pancreas); therefore, if symptoms such as abdominal pain or vomiting occur, inform medical personnel immediately. Patients with type 1 diabetes or diabetic ketoacidosis should not take this medication, and those with severe allergies to this medication or its ingredients should also avoid it. Patients with decreased renal function need dosage adjustments for this medication, so renal function tests should be conducted and usage should follow the physician's guidance. Common side effects noted in clinical trials include cold symptoms, headache, upper respiratory infections, and some patients may experience hypoglycemic symptoms, so caution is necessary. The risk of hypoglycemia may increase when used in conjunction with other hypoglycemic agents or insulin, so blood glucose levels should be monitored regularly while taking this medication, and dosage adjustments may be necessary. If severe arthralgia or skin blisters occur during treatment, notify the physician immediately and discontinue medication. Pregnant or breastfeeding women are advised not to take this medication, and it is not recommended for children under 18 as safety and efficacy have not been established. Elderly patients may experience decreased renal function, so renal function evaluation is needed before administration, and regular monitoring is also required during treatment. In cases of overdose, gastrointestinal decontamination or monitoring, including electrocardiograms, should be performed, and some drugs may be removed via hemodialysis. This medication has relatively few interactions with other drugs, but it is important to consult a physician or pharmacist when taking certain medications.

Serious side effects

• Hives, angioedema, chest tightness, difficulty breathing, cold sweats, pallor, and other severe allergic reactions.
• Severe skin reactions (including Stevens-Johnson syndrome with rash, blisters, skin peeling, etc.)
• Acute pancreatitis (including potentially fatal/non-fatal hemorrhagic or necrotizing pancreatitis)
• Acute renal failure (sometimes requiring dialysis)
• Severe and disabling arthralgia
• Bullous pemphigoid
• Elevated liver enzymes and liver abnormalities such as jaundice of the skin/eyes.

Mild side effects

• Headache
• upper respiratory infection
• nasopharyngitis
• constipation
• vomiting
• myalgia
• limb pain
• back pain
• pruritus
• thrombocytopenia

Store this medication in a tightly sealed container to prevent air or moisture from entering and keep it at a temperature between 1 and 30 degrees Celsius. This storage will help maintain the medication's effectiveness over time.

Appearance

Bright yellow-orange round film-coated tablet

Package unit

100 tablets/bottle, 30 tablets/bottle