Hugliya Tablets 100mg (Sitagliptin Hydrochloride Monohydrate)

Adult dose

This medication is administered as 100 mg once daily for monotherapy or combination therapy, with a maximum daily dose of 100 mg. It can be taken without regard to meals. For patients with renal impairment, dosage adjustment may be necessary according to renal function. 1. In patients with mild renal impairment (eGFR 60 to less than 90), no dosage adjustment is required. 2. In patients with moderate renal impairment (eGFR 45 to less than 60), dosage adjustment is not required.

This medication may cause severe allergic reactions after administration, so symptoms such as rashes, hives, or breathing difficulties should prompt immediate consultation with a doctor while taking the medication. This medication can potentially cause acute pancreatitis, a serious pancreatic condition, so patients must inform healthcare providers immediately of any abdominal pain, vomiting, or persistent abdominal discomfort after taking it. It should not be used in patients with type 1 diabetes or diabetic ketoacidosis, nor in those who are allergic to this medication or its ingredients. Patients with impaired kidney function may have difficulty excreting the drug, so dosage adjustments or careful use under the guidance of a physician are necessary. When taking this medication, hypoglycemia risk exists; thus, careful monitoring of blood sugar changes is particularly important when used with insulin or Sulfonylureas. If serious joint pain or blistering skin conditions occur, discontinue the medication immediately and consult a specialist. Use during pregnancy or breastfeeding is not recommended, and safety in pediatric patients has not been adequately confirmed. In elderly patients, kidney function may decline, so regular assessments of kidney function before and during use are important. In the case of overdose, general emergency treatment should be initiated, and blood dialysis may be required for drug removal, hence immediate medical attention should be sought.

Serious side effects

Hives, severe swelling (angioedema), allergic reactions (anaphylaxis), severe allergic reactions, severe skin adverse reactions (Stevens-Johnson syndrome, exfoliative skin diseases), acute pancreatitis (fatal/non-fatal hemorrhagic or necrotizing pancreatitis), difficulty breathing (respiratory problems), liver abnormalities (elevated liver enzymes, jaundice), severe and debilitating joint pain, bullous pemphigoid, severe hypoglycemia, acute kidney failure, cardiac arrest

Mild side effects

• Upper respiratory infections
• nasopharyngitis
• headaches
• constipation
• vomiting
• muscle pain
• limb pain
• back pain
• pruritus
• thrombocytopenia

This medication should be stored in a tightly sealed container to prevent air or moisture ingress and should be kept at room temperature between 1 and 30 degrees Celsius. This will help maintain the efficacy of the medication.

Appearance

Bright yellow-orange round film-coated tablets

Package unit

100 tablets/bottle, 30 tablets/bottle