Hugliya Tablet 25 mg (Sitagliptin Hydrochloride Hydrate)

Adult dose

This medication is administered once daily at a dose of 100 mg for monotherapy or combined therapy, with a maximum daily dose of 100 mg. It can be taken irrespective of meals. In patients with renal impairment, dosage adjustment is necessary according to kidney function. There is no need for dosage adjustment in patients with mild to moderate renal impairment (eGFR 45 or higher but less than 90). In patients with moderate renal impairment (eGFR 30 or more but less than 45), a dose of 50 mg is administered once daily.

This medication may cause severe allergic reactions after administration, so if symptoms such as skin rashes or breathing difficulties occur, it should be discontinued immediately and medical advice should be sought. There is also a risk of serious pancreatic inflammation known as pancreatitis, so if symptoms such as abdominal pain, nausea, or vomiting appear, it is important to visit a hospital quickly. This medication should not be used in patients with type 1 diabetes or those who have specific allergic reactions. Patients with impaired kidney function may experience drug accumulation in the body; therefore, dosage adjustment or cautious use is necessary, and periodic kidney function tests are recommended. Due to the risk of hypoglycemia, caution should be exercised when taking it with other antidiabetic agents like insulin or sulfonylureas, and dosage adjustments may be necessary if required. Severe joint pain or skin blistering has been reported on rare occasions; if such symptoms occur, contact a doctor immediately. It is recommended that pregnant or breastfeeding women do not take this medication, and safety has not been established in children under 18 years of age. In the case of overdose, appropriate treatment should be initiated, such as gastrointestinal decontamination and cardiac monitoring, and blood dialysis may be conducted if necessary to remove some of the medication.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing, cold sweat, pallor (severe allergic reaction), rash, exfoliative skin disease, Stevens-Johnson syndrome, skin peeling, pain in mouth/eye mucosa (severe skin adverse reactions), shortness of breath or difficulty breathing, asthma attacks, abnormalities in breathing accompanied by cough and fever, liver-related symptoms (jaundice) are not specifically mentioned, but include elevated liver enzymes.

Mild side effects

• Upper respiratory tract infection
• nasopharyngitis
• constipation
• vomiting
• headache
• muscle pain
• limb pain
• back pain
• pruritus
• thrombocytopenia

This medication should be stored in a sealed container to prevent exposure to air or moisture. It is also important to avoid excessively hot or cold places, and it is best to store it at room temperature between 1°C and 30°C.

Appearance

Bright yellow-orange round film-coated tablet

Package unit

100 tablets/bottle, 30 tablets/bottle