Epalle (Epalerastat)

Adult dosage

Adults: 1 tablet (epalrestat 50mg) per dose, 3 times daily before meals. Adjust the dose as appropriate according to age and symptoms.

This medication may reduce platelet count, so if symptoms of thrombocytopenia appear, discontinue use immediately. There is a risk of liver abnormalities, so if symptoms such as acute hepatitis, liver dysfunction, jaundice, or liver failure occur, stop taking the drug and seek appropriate treatment. Hypersensitivity reactions such as skin rash, itching, red spots, and blisters may occur, and if these symptoms appear, the drug should be discontinued. Gastrointestinal symptoms such as abdominal pain, nausea, vomiting, diarrhea, loss of appetite, abdominal bloating, constipation, and heartburn may occur, so be attentive to symptoms. It may affect kidney function, potentially leading to decreased urine output, increased frequency of urination, and elevated blood levels of BUN and creatinine, so regular monitoring is necessary. Anemia or leukopenia may be noted in blood tests, so consult with a doctor in case of unusual symptoms. Other symptoms that may appear include fatigue, dizziness, headache, muscle stiffness, weakness, limb pain, chest discomfort, palpitations, edema, facial flushing, sensory abnormalities, hair loss, petechial skin bleeding, and fever, so observe the body's condition closely. When treating diabetes, it should be used alongside dietary control, exercise, other hypoglycemic agents, and insulin therapy, and it is recommended for patients with HbA1c levels above 7.0%. Its effectiveness in diabetic peripheral neuropathy patients is not clearly established, so caution is required. During medication, carefully monitor for changes in condition, and if no effects are observed after 12 weeks of use, consider changing to alternative treatment methods. Women who are pregnant or may become pregnant should take this medication only if the benefits outweigh the risks, as safety during pregnancy has not been established. Breastfeeding should be avoided during the use of this drug, as animal studies have confirmed transmission of the medication through breast milk. Safety in children has not been established, so use is not recommended.

• Thrombocytopenia
• acute hepatitis
• liver dysfunction
• jaundice
• liver failure
• rash
• pruritus
• erythema
• vesicles
• elevated AST (GOT)

This medication should be stored in a tightly closed container to avoid exposure to air or moisture, and it is safe to store at room temperature between 1 to 30 degrees Celsius.

Appearance

White round film-coated tablet

Package unit

Bottle - 30 tablets/bottle, Bottle - 300 tablets/bottle