Sitagliptin Tablets 100 mg (Sitagliptin Hydrochloride Monohydrate)

Adult dosage

This medication is to be administered once daily at a dose of 100 mg, either as monotherapy or in combination therapy, with a maximum daily dose of 100 mg. It can be taken regardless of meals. Dosage adjustment for patients with renal impairment: Mild to moderate renal impairment (eGFR 45 to less than 90) does not require dosage adjustment. Patients with moderate renal impairment (eGFR 30 to less than 45) are administered 50 mg once daily.

This medication may cause severe allergic reactions after administration; therefore, if symptoms such as skin rash or difficulty in breathing occur, it should be discontinued immediately, and a doctor should be consulted. There is a risk of developing serious pancreatic diseases such as pancreatitis while taking this medication; hence, if symptoms like abdominal pain, vomiting, or loss of appetite appear, immediate notification to healthcare personnel is necessary. This medication should not be used in patients with type 1 diabetes or diabetic ketoacidosis, and those who are allergic to this drug or its components should avoid it. Patients with impaired renal function need dosage adjustments; thus, renal function tests should be performed, and usage should follow a doctor's guidance. Hypoglycemia may occur when taking this drug alone or in combination with other antidiabetic medications; therefore, it is essential to be aware of hypoglycemic symptoms and check blood sugar levels frequently if necessary. During treatment with this medication, side effects such as headache, upper respiratory infections, rhinitis, diarrhea, nausea, indigestion, dizziness, increased blood triglycerides, elevated low-density lipoprotein, hyperglycemia, weight loss, hypertension, hypernatremia, and erectile dysfunction may occur, so if symptoms are severe or persistent, consultation with medical professionals is advised. If symptoms like severe joint pain or blisters on the skin appear, the use of this medication should be stopped immediately and specialist care should be sought. Pregnant or breastfeeding women are advised to avoid this medication, and its safety has not been established in children or adolescents under 18 years of age. Elderly patients are at risk of reduced renal function, so regular kidney function tests before and after taking this medication are necessary. In case of overdose, it is essential to visit a hospital immediately for appropriate treatment, and this drug can be partially removed by hemodialysis. There may be interactions with other medications, so inform healthcare professionals of any other medications being taken.

Serious side effects

Urticaria, severe swelling (angioedema), chest tightness, difficulty breathing, anaphylaxis, Stevens-Johnson syndrome, severe skin reactions, exfoliative dermatitis, acute pancreatitis, shortness of breath or difficulty breathing, asthma attacks, liver dysfunction (jaundice), severe headache, seizures, altered consciousness, visual disturbances, paralysis, decreased urine output, severe edema, increased blood pressure, severe hypoglycemia, acute renal failure, severe and disabling

Mild side effects

• Upper respiratory infection
• rhinitis
• constipation
• vomiting
• headache
• myalgia
• limb pain
• back pain
• pruritus
• diarrhea

This medication should be stored in a tightly sealed container to prevent air exposure and should be kept at room temperature between 1 and 30 degrees Celsius for safety. This ensures that the effectiveness of the medication is maintained and prevents degradation.

Appearance

Bright yellow-orange round film-coated tablets

Package unit

100 tablets/bottle, 30 tablets/bottle