Sitagliptin 25mg Tablets (Sitagliptin Hydrochloride Monohydrate)

Adult dosage

This medication is administered once daily at a dose of 100 mg, whether as monotherapy or in combination therapy, with a maximum daily dose of 100 mg. It can be taken without regard to meals. For patients with renal impairment, a daily dose of 50 mg is given for moderate renal impairment (glomerular filtration rate 30-45 mL/min/1.73 m2). A daily dose of 25 mg is given for patients with severe renal impairment or end-stage renal disease (glomerular filtration rate below 15).

This medication may cause severe allergic reactions; if symptoms such as skin rash or difficulty breathing occur after administration, it should be discontinued immediately, and a doctor should be consulted. Severe inflammation of the pancreas known as pancreatitis can occur, so if symptoms such as abdominal pain, vomiting, or nausea arise, stop taking this medication immediately and inform a healthcare provider. This medication should not be used in patients with type 1 diabetes or diabetic ketoacidosis, nor should it be taken by patients who are hypersensitive to this medication or its components. Patients with reduced kidney function may experience slower excretion of this medication, so it should be taken in a lower dosage, and kidney function tests should be performed regularly. During treatment, symptoms similar to a cold, headache, dyspepsia, and diarrhea may occur; consult a doctor if these symptoms persist or worsen. The risk of hypoglycemia increases when taken with other hypoglycemic agents, especially insulin or sulfonylureas, so blood glucose levels should be checked frequently and medication dosages adjusted as necessary. If severe or persistent joint pain occurs during treatment, it may be related to the medication, so consult a doctor to decide whether to discontinue it. Rarely, blistering similar to pemphigus may develop on the skin, so report any skin abnormalities to a healthcare provider immediately. The use of this medication in pregnant or breastfeeding women is not recommended, and its safety and efficacy have not been established in children under 18 years of age. In case of overdose, general treatment measures such as removal of the medication from the gastrointestinal tract are implemented, and, if necessary, hemodialysis can be used to remove the drug. This medication has a low potential for drug interactions, but it is important to consult a healthcare provider if taking other medications, especially for patients with heart or kidney disease.

Serious side effects

Severe hypersensitivity reactions (anaphylaxis, angioedema, hives, rash, skin vasculitis, Stevens-Johnson syndrome, exfoliative skin disease), acute pancreatitis (including hemorrhagic or necrotizing pancreatitis), acute renal failure (requiring dialysis), severe and disabling arthralgia, blistering similar to pemphigus, liver abnormalities (although jaundice-related symptoms have not been reported, elevated liver enzymes have been observed), serious neurological symptoms (such as severe headache, seizures, etc. have been reported)

Mild side effects

• Upper respiratory infection
• pharyngitis
• headache
• abdominal pain
• nausea
• diarrhea
• constipation
• vomiting
• myalgia
• limb pain

This medication should be stored in a tightly sealed container to prevent air and moisture from getting in, ideally at room temperature between 1 and 30 degrees Celsius. Proper storage helps maintain the medication's effectiveness and prevents deterioration.

Appearance

Bright yellow-orange round film-coated tablets

Package unit

100 tablets/bottle, 30 tablets/bottle