Sitdime 100 mg Tablet (Sitagliptin Hydrochloride Hydrate)

Adult dose

This medication is administered once daily at a dose of 100 mg, either as monotherapy or in combination, with a maximum daily dose of 100 mg. It can be taken regardless of meals. Dosage adjustments are required based on kidney function. - Mild renal impairment (eGFR ≥ 60 and < 90 mL/min/1.73 m2): No dosage adjustment needed - Moderate renal impairment (eGFR ≥ 45 and < 60 mL/min/1.73 m2): No dosage adjustment needed

This medication is used for the treatment of diabetes and may cause serious allergic reactions in some patients after administration. These allergic reactions may include symptoms such as skin rash, angioedema, and in severe cases, anaphylaxis; therefore, if skin or respiratory symptoms appear after taking the medication, it should be discontinued immediately and medical attention sought. Furthermore, this medication can cause severe side effects such as pancreatitis, which is inflammation of the pancreas. If abdominal pain, vomiting, or severe abdominal discomfort occurs during treatment, a hospital visit should be made immediately. This medication should not be administered to patients with type 1 diabetes or diabetic ketoacidosis, and it should also not be used in individuals with a severe allergy to the drug or its components. Patients with impaired kidney function may experience delayed excretion of this medication, necessitating dosage adjustments, and regular kidney function tests are important. Patients in clinical trials who took this medication commonly experienced side effects such as upper respiratory tract infections, headaches, nasopharyngitis, diarrhea, abdominal pain, and others. In particular, when taken in conjunction with insulin or sulfonylureas, the risk of hypoglycemia may increase, so careful monitoring of blood sugar changes is necessary. This medication is not recommended for pregnant or breastfeeding women, and its safety in children under 18 years has not been established. Elderly individuals may have a higher risk of reduced kidney function, thus requiring dosage adjustments and kidney function monitoring. In case of overdose, general supportive care measures should be taken, and blood dialysis may be considered for removal if necessary. If symptoms such as joint pain or skin blistering appear during the use of this medication, consult a doctor immediately; these symptoms may improve after discontinuation of the medication. Lastly, interactions with other medications are generally minimal; however, caution is required when taken in conjunction with specific drugs, so patients should inform healthcare providers about any medications they are currently taking.

Serious side effects

Hives, severe swelling (edema), anaphylaxis, angioedema, Stevens-Johnson syndrome, severe skin adverse reactions, acute pancreatitis, difficulty breathing, respiratory issues, acute renal failure, hepatic abnormalities (jaundice), severe joint pain with disability, bullous pemphigoid, thrombocytopenia, rhabdomyolysis, severe neurological symptoms (seizures, altered consciousness, visual disturbances, paralysis), cardiac arrest, hypertension, falls, diabetic complications,

Mild side effects

• Upper respiratory tract infections
• nasopharyngitis
• headaches
• diarrhea
• nausea
• dyspepsia
• dizziness
• weight loss
• increased triglycerides
• elevated low-density lipoprotein

This medication should be stored in a tightly sealed container to prevent exposure to air or humidity, and kept at room temperature between 1 and 30 degrees Celsius. This storage method helps maintain the medication's effectiveness for an extended period.

Appearance

Light brown, round, biconvex, film-coated tablet

Package unit

28 tablets/box [14 tablets/PTP x 2]