SITD-M tablet 25 milligrams (Sitagliptin hydrochloride monohydrate)

Adult dose

This medication is administered once daily at a dose of 100 mg for monotherapy or combination therapy, with a maximum daily dose of 100 mg. It can be taken regardless of meals. In patients with kidney impairment, dosage adjustments are required based on renal function. In patients with mild to moderate renal impairment (eGFR 45–90 mL/min/1.73 m2), dosage adjustments are not necessary.

This medication may cause severe allergic reactions in some patients. Such reactions can occur within the first 3 months after starting the medication, so careful monitoring is necessary. Moreover, during treatment with this medication, pancreatitis (inflammation of the pancreas) may occur, so if symptoms such as abdominal pain or vomiting appear, consultation with a physician is required immediately. Patients with type 1 diabetes or diabetic ketoacidosis should not use this medication, nor should patients with a history of allergic reactions to this medication or its components. Patients with impaired renal function should adjust the dosage of this medication, following their physician's instructions. During the treatment with this medication, side effects such as cold symptoms, headache, indigestion, diarrhea, and dizziness may occur, and patients may also experience hypoglycemia, making thorough blood sugar management essential. Particularly, caution is needed as the risk of hypoglycemia may increase when used in combination with insulin or sulfonylureas. This medication has been reported to seldom cause serious side effects such as arthralgia or blistering conditions resembling bullous pemphigoid, and patients should report any such symptoms to their physician immediately. It is recommended that women who are pregnant or breastfeeding avoid using this medication, and safety and efficacy have not been established for children or adolescents under 18 years of age. Elderly patients should be monitored for reduced renal function, necessitating dosage adjustments and regular renal function checks. In case of overdose, general treatment should be administered, and blood dialysis may be considered if necessary. Finally, this medication does not significantly interact when taken with several other medications, but interactions may occur with some drugs, so it is crucial to consult a physician or pharmacist regarding any other medications being taken.

Serious side effects

• Hives
• severe swelling (angioedema)
• anaphylaxis
• rash
• Stevens-Johnson syndrome
• cutaneous vasculitis
• acute pancreatitis
• acute renal failure
• cardiac arrest
• severe and disabling arthralgia

Mild side effects

• Nasopharyngitis
• upper respiratory tract infection
• headache
• diarrhea
• nausea
• constipation
• abdominal pain
• myalgia
• limb pain
• back pain

This medication should be stored in a tightly sealed container to prevent air ingress, and the storage temperature must be maintained between 1 and 30 degrees Celsius at room temperature. Storing it in this manner will help maintain its efficacy for longer.

Appearance

Pink, round, biconvex film-coated tablets

Package unit

28 tablets/box [14 tablets/PTP X 2]