Therabia Tablets 50 mg (Sitagliptin Hydrochloride Hydrate)

Adult dose

For monotherapy or combination therapy, administer 100 mg once daily, with a maximum daily dose of 100 mg. In patients with renal impairment, dosage adjustment is required based on kidney function. - In patients with mild to moderate renal impairment (eGFR 45 to less than 90), no dosage adjustment is necessary. - In patients with moderate renal impairment (eGFR 30 to less than 45), administer 50 mg once daily. - In patients with severe renal impairment

This medication is used for the treatment of diabetes and helps in blood sugar control. Points to be cautious about during usage include the possibility of allergic reactions to this medication; therefore, if there are symptoms such as skin rash, breathing difficulties, or swelling of the face or neck, immediately discontinue the medication and consult a doctor. Furthermore, serious pancreatic inflammation known as pancreatitis may occur, so if symptoms such as abdominal pain, nausea, or vomiting appear after taking this medication, inform medical personnel immediately. It should not be used in patients with type 1 diabetes or diabetic ketoacidosis, and those with hypersensitivity to this drug or its components should also avoid taking it. Patients with impaired kidney function may require dosage adjustments due to increased drug concentration, and regular kidney function checks before and during treatment are advisable. Hypoglycemia may occur during the use of this medication; therefore, when taken with other hypoglycemic agents like insulin or sulfonylureas, attention should be paid to hypoglycemic symptoms, and dosage adjustments of other medications may be necessary. Additionally, rare side effects such as severe joint pain or bullous pemphigoid, which causes blisters on the skin, may occur, and symptoms should be reported to a doctor immediately if they arise. The use of this medication is not recommended during pregnancy or breastfeeding, and safety has not been established in children and adolescents under 18 years of age. In the event of overdose, gastrointestinal removal of the drug and clinical monitoring including ECG may be necessary, and in some cases, blood dialysis may be required to eliminate some of the medication. Finally, this medication has been reported to pose no cardiovascular safety issues and does not increase the risk of heart disease or heart failure.

Serious side effects

• Hives, severe swelling (angioedema), tightness in the chest, difficulty breathing, cold sweat, pallor (severe allergic reaction)
• Severe rash with high fever, blisters, skin shedding, pain in oral/ocular mucosa (severe skin abnormal reactions)
• Difficulty breathing or shortness of breath, asthma attacks, cough + abnormal breathing with fever
• Yellowing of skin or eyes (jaundice), extreme lethargy (liver abnormality)
• Sudden and very severe headache, lightning-like pain

Mild side effects

• Upper respiratory tract infection
• nasopharyngitis
• constipation
• vomiting
• headache
• muscle pain
• limb pain
• back pain
• pruritus
• diarrhea

This medication should be stored in a tightly sealed container to prevent air and moisture from entering, and it is advisable to keep it at a temperature between 1 degrees Celsius and 30 degrees Celsius at room temperature. Storing it this way will help maintain the effectiveness of the medication for a long period.

Appearance

Light apricot-colored, round, biconvex film-coated tablets

Package unit

28 tablets/PTP [(14 tablets/PTP x 2)]