Trusita Tablets 50 mg (Sitagliptin Hydrochloride Monohydrate)

Adult dosage

The dosage is 100 mg once daily, either as monotherapy or in combination therapy, with a maximum daily dose of 100 mg. This medication can be taken regardless of meals. For patients with renal impairment, no dosage adjustment is necessary for mild to moderate renal impairment (estimated Glomerular Filtration Rate [eGFR] 45 - 90 mL/min/1.73 m2).

This medication can rarely cause severe allergic reactions. Particularly, hypersensitivity reactions such as anaphylaxis, angioedema, and severe skin disorders can occur within 3 months after starting the medication, so caution is advised. If such symptoms are suspected, immediately stop taking the medication and consult a physician. Furthermore, this medication can cause a serious side effect known as pancreatitis, which is inflammation of the pancreas; therefore, if symptoms such as abdominal pain, nausea, or vomiting occur during use, it is crucial to visit a hospital immediately. This medication is not to be administered to patients with type 1 diabetes or diabetic ketoacidosis. Patients who are allergic to this medication or its components must also refrain from taking it. Patients with impaired kidney function should have their dosage adjusted, and it is important to have regular kidney function tests. When taking this medication alone or in combination with other diabetes medications, hypoglycemia may occur; therefore, if used with insulin or sulfonylureas, hypoglycemic symptoms should be monitored closely. If symptoms such as severe joint pain or blisters appear resembling a bullous pemphigoid, it is essential to inform a doctor immediately, and if necessary, stop taking the medication. Women who are pregnant or breastfeeding should not take this medication, and its safety in children or adolescents under 18 has not been established. Elderly patients may have decreased kidney function; thus, it is advisable to consult a physician before use and dosage adjustments may be necessary. In case of overdose, general treatment should be administered, and if necessary, the drug can be removed through dialysis. This medication is known to have no issues concerning cardiovascular safety and does not increase heart-related risks even with prolonged use. It is important to consult medical personnel immediately if uncomfortable symptoms or adverse reactions occur during use.

Serious side effects

Hives, severe swelling (angioedema), chest tightness, difficulty breathing (including anaphylaxis), cold sweat, paleness, severe allergic reactions, severe rash with fever, blisters, skin peeling, mouth/eye mucosal pain, severe cutaneous reactions (including Stevens-Johnson Syndrome), difficulty breathing or shortness of breath, asthma attacks, respiratory abnormalities accompanied by cough and fever, breathing difficulties, yellowing of the skin or eyes (jaundice)

Mild side effects

• Upper respiratory tract infection
• nasopharyngitis
• headache
• constipation
• vomiting
• muscle pain
• limb pain
• back pain
• pruritus
• thrombocytopenia

This medication should be stored in an airtight container and kept at room temperature between 1 to 30 degrees Celsius. Proper storage will help maintain the effectiveness of the medication for a longer period.

Appearance

Light apricot-colored, round, biconvex film-coated tablets

Package unit

PTP - 28 tablets/box [(14 tablets/PTP×2)]