Atovanjette Tablet 10/20 mg

Adult dosage

This medication is administered once daily without regard to meals. For primary hypercholesterolemia, the dosage range is 10/10 mg to 10/80 mg per day, with a starting dose of 10/10 mg or 10/20 mg recommended. For patients requiring significant LDL-cholesterol reduction, a daily dose of 10/40 mg is advised. After initiating therapy or adjusting dosage, check blood lipid levels at intervals of more than 2 weeks for dosing.

This medication has been reported to have a rare side effect of rhabdomyolysis, which may cause severe abnormal muscle conditions. If severe muscle pain or weakness symptoms occur, contact a physician immediately, and if necessary, discontinue the medication. Women who are pregnant or breastfeeding, or those with an allergy to any components of this medication, severe liver dysfunction, or muscle disorders should not take this medication. Patients with specific antiviral drugs or genetic issues like lactose intolerance should also refrain from using this medication. Patients with a history of alcoholism, liver disease, diminished kidney function, hypothyroidism, or elderly patients should take special precautions while using this medication and should be regularly monitored for muscle-related abnormalities. This medication may elevate liver enzyme levels, and liver function tests should be conducted before and during use. If any liver abnormalities occur, discontinue the medication promptly. Blood sugar levels may increase during the course of treatment, so patients at risk of diabetes must manage their blood sugar levels diligently. Combining this medication with certain antibiotics, antifungals, antivirals, or other lipid-lowering agents may increase the risk of muscle damage; consult with a physician or pharmacist regarding any concurrent medications. Women of childbearing potential should ensure adequate contraception while taking this medication and should avoid it if there is a possibility of pregnancy. Symptoms such as dizziness or muscle pain may occur, requiring caution when driving or operating machinery. Safety for pediatric patients has not been established and is therefore not recommended. In case of overdose, there are no specific antidotes, and treatment should be symptomatic, with regular monitoring of liver function and muscle enzyme levels. This medication should be kept out of reach of children and should not be transferred to different containers.

Serious side effects

Urticaria, severe swelling (edema), chest tightness, difficulty breathing, cold sweat, pallor, severe rash with fever, blisters, skin peeling, pain in oral/ocular mucosa, shortness of breath or difficulty breathing, asthma attacks, respiratory issues accompanied by cough and fever, yellowing of skin or eyes (jaundice), severe drowsiness, sudden and severe headaches, lightning headaches, seizures, altered consciousness, visual disturbances, paralysis, urination.

Mild side effects

• Muscle pain
• abdominal pain
• nausea
• headache
• dizziness
• joint pain
• muscle weakness
• musculoskeletal pain
• hyperkalemia
• bronchitis

Store this medication in a tightly sealed container to protect it from air and moisture. It is advisable to maintain room temperature between 1 to 30 degrees Celsius for storage. Proper storage can safely preserve the medication's efficacy.

Appearance

White, bilayer convex film-coated tablet

Package unit

30 tablets/box [10 tablets/PTP*3]